NBME 23 Phase 2 (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

Retired NBME 23 Answers

nbme23/Block 1/Question#5 (reveal difficulty score)
A study is conducted to examine the ...
Phase 2 🔍 / 📺 / 🌳 / 📖
tags: FA19p256 clinical_trials biostats

+6 upvote downvote
submitted by ∗lfsuarez(160)

get full access to all content ⋅ pick a username

Phase II studies test the efficacy of a drug. This second phase of testing can last from several months to two years, and involves up to several hundred affected patients.

get full access to all content ⋅ pick a username

polyomavirus FA2019 p256. Does the drug SWIM (1. Safe 2. Work 3. Improve from standard 4. Market surveillance) +3

cherrypie key here is acknowledging that "100-200" patients is considered small/moderate, NOT "large". Large = stage 3 +1

drdoom More extensive discussion of clinical trials in this NBME 21 thread (so, heads-up SPOILERS ALERT) -> https://nbmeanswers.com/exam/nbme21/633#1782 +

drdoom Briefly, it’s not size of study that defines the phase (although that’s not a bad heuristic). Phases are determined by study goal: 1 - can I give this drug to normal humans, exclusive, without killing them? (“first, do no harm.”) 2 - can I give this drug to sick humans, exclusive, and provide ANY benefit whatsoever? (“for ppl with disease, does giving the drug do better than not giving anything at all?”) 3 - is it better than the current gold standard? (“does it do better than what’s already been approved?”) and, finally, 4 - did we miss anything that phase 1,2,3 didn’t catch? (“surveil the market for adverse effects that couldn’t be captured in phase 1,2,3”) +

+0 upvote downvote
submitted by ∗usmile1(154)

get full access to all content ⋅ pick a username

phase 2 = moderate number of patents with the disease of interest. Assesses treatment efficacy, optimal dosing, and adverse effects.

phase 3 = LARGE number of patients randomly assigned to either treatment group or the standers of care . Compares the new treatment to the current standard of care to see if there is any improvement.

FA19 p 256

get full access to all content ⋅ pick a username

usmile1 standard* +1

Must-See Comments from nbme23

ferrero on Precapillary resistance
yotsubato on 99%
sne on Triglyceride
sajaqua1 on Area labeled ‘D’ (Spinothalamic tract, right)
stinkysulfaeggs on Hypoglycemia
hayayah on Iris
soph on Peak inspiratory pressure (alveolar): ...
seagull on Area labeled ‘C’ (Cranial nerve 8: ...
water on Dietary change
wired-in on 28.8
beeip on Binding of permeable ligand to nuclear ...
thomasalterman on Hypoglycemia
yotsubato on Inhibition of the cytochrome P450-dependent ...
seagull on Decreased sodium bicarbonate reabsorption in ...