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NBME 23 Answers

nbme23/Block 3/Question#30

A 20-year-old woman comes to the physician because ...


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SLE is associated with deficiency of early complement proteins(eg. C1q, C4, C2). (FA 19, pg. 462)

tinydoc  Am I the only one who has never heard of C1Q? +2  

Complement is important for removing immune complexes, so patients with complement deficiencies *(c1-c4) are more likely to develop SLE. C1q is a better answer than than MBL (D) b/c the MBL pathway is triggered by bacteria.

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submitted by axsa19(4),

C1q, C1r, and C1s form the C1 complex. Any time you see C1 with any of these three letters "qrs" think of C1 which is the first component of the classical complement pathway