NBME 23 Decreased gluconeogenesis (NBME Answers)

+17
submitted by sajaqua1(519),

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yotsubato His glycogen concentration is high, since he's been hyperglycemic with lots of insulin until birth. +3

alexb Also explains why he's 12 pounds. +3

krewfoo99 Also, think of it like this: Insulin causes hypoglycemia, thus this baby must have increased insulin. It is also an anaobolic hormone which is clear by the babys weight. Insulin increases glycogen synthase activity, and causes an increase in concentrations of glycogen. Decrease in insulin would do exactly the opposite +1

tyrionwill fetus of a mom with DM will develop pancreatic beta cell hyperplasia, which leads to insulinemia trying to reduce the blood glucose. after birth, the excessive blood glucose will be automatically withdrawn while the insulin at that moment is still high, which leads to hypoglycemia. +2