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NBME 23 Answers

nbme23/Block 1/Question#19

Unlike the DNA polymerases found in Escherichia ...

Mistakes in transcription are not transmitted to progeny

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submitted by keycompany(125),

This question is disguised. What they are really asking is "what is the sole determinant of species survival"? The only answer is the ability to procreate. Because DNA Polymerase has proof-reading activity, progeny will be unaffected by RNA Polymerases lack of proof-reading activity.

ls3076  the phrasing of this explanation doesnt make sense to me. +2  
ls3076  oh wait sorry i just read it again. So instead of proofreading how are errors handled with RNA? +  
thomasburton  Think the point is basically although errors with RNA polymerase make make the bacterium not very good at infecting or killing or whatever it does not affect replication as it is not used during replication! +1  

 +1  upvote downvote
submitted by seagull(446),


Here is a little bit on proofreading.Hope it helps

So basically what this is saying that DNA will be transmitted to the progeny not RNA. So DNA will replicate in the G2 phase and transfer of DNA material to progeny will occur in the M phase. The RNA may be mutated and making defective products, but this will not transmit into the progeny, thus not affecting species survival based on RNA mutations.