NBME 23 It increases plasma concentrations of other PIs also metabolized by cytochrome P450 (NBME Answers)

need help with your account or subscription? click here to email us (or see the contact page)

search for anything ⋅ score predictor (“predict me!”)

You must be logged in to vote!

Retired NBME 23 Answers

nbme23/Block 1/Question#8 (reveal difficulty score)
A 30-year-old man with HIV infection comes to ...
It increases plasma concentrations of other PIs also metabolized by cytochrome P450 🔍 / 📺 / 🌳 / 📖
tags: biochem p450 pharm drug_interactions

+10 upvote downvote
submitted by ∗step420(32)

get full access to all content ⋅ pick a username

Ritonavir inhibits CYP450! So you can use it to boost the concentration of the other Protease inhibitors by preventing their metabolism by CYP450!

get full access to all content ⋅ pick a username

mousie who knew +7

sympathetikey Right on (thanks sketchy) +10

mguan1993 MAGIC RACKS is a good mnemonic ive heard for 450 inhibitors (macrolides, amiodarone, grapefruit, cimetidine, RITONAVIR, alcohol (chronic), cipro, ketoconazole, sulfa +6

criovoly "CRACK AMIGOS" Cimetidine Ritonavir Amiodarone Ciprofloxacion Ketoconazole Acute alcoholism Macrolides Isoniasid Grapefruit juice Omeprazole Sulfonamides +7

drzed Macrolides EXCEPT azithromycin -- they like to trick you with that one. +3

steatorrhea chronic alcohol induces 450, acute alcohol inhibits 450 +3

an1 This was added in FA inhibitors list last year I think. SICKFACES.COM when i AM Really drinking Grapefruit juice +

You must be logged in to vote!

+0 upvote downvote
submitted by kungfupanda(5)

get full access to all content ⋅ pick a username

Check Pg 203 in FA . its clearly given. but i choose the wrong answer!

get full access to all content ⋅ pick a username

You must be logged in to vote!

Must-See Comments from nbme23

ferrero on Precapillary resistance
yotsubato on 99%
sne on Triglyceride
sajaqua1 on Area labeled ‘D’ (Spinothalamic tract, right)
stinkysulfaeggs on Hypoglycemia
hayayah on Iris
soph on Peak inspiratory pressure (alveolar): ...
seagull on Area labeled ‘C’ (Cranial nerve 8: ...
water on Dietary change
wired-in on 28.8
beeip on Binding of permeable ligand to nuclear ...
thomasalterman on Hypoglycemia
yotsubato on Inhibition of the cytochrome P450-dependent ...
seagull on Decreased sodium bicarbonate reabsorption in ...