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NBME 21 Answers

nbme21/Block 4/Question#21

A 47-year-old man is treated with colchicine for ...

Tubulin polymerization

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submitted by chillqd(8),

The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.

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submitted by pparalpha(19),

inhibition of microtubule polymerization → inhibitis phagocytosis of urate crystals, leukocyte activation and migration, and cell chemotaxis.