need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 21 Answers

nbme21/Block 4/Question#21 (reveal difficulty score)
A 47-year-old man is treated with colchicine ...
Tubulin polymerization ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +5  upvote downvote
submitted by โˆ—pparalpha(93)
get full access to all contentpick a username

inhibition of microtubule polymerization โ†’ inhibitis phagocytosis of urate crystals, leukocyte activation and migration, and cell chemotaxis.

get full access to all contentpick a username
teepot123  fa 19 pg 476 +



 +2  upvote downvote
submitted by โˆ—chillqd(44)
get full access to all contentpick a username

The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.

get full access to all contentpick a username
castlblack  FA mnemonic = Microtubules Get Constructed Very Poorly: Mebendazole (antihelminthic), Griseofulvin (antifungal), Colchicine (antigout), Vincristine/Vinblastine (anticancer), Paclitaxel (anticancer). A = dont confuse colchicine with celecoxib. celecoxib is a 'celective' COX inhibitor B = ziLEUton = leukotriene inhibitor for asthma +3



Must-See Comments from nbme21

nosancuck on Absorption atelectasis
assoplasty on Free T4
seagull on GM2
lnsetick on Apocrine
niboonsh on NMDA receptors are blocked by Mg2+ at the ...
drdoom on Deletion of a hydrophobic amino acid ...
hayayah on HCO3โˆ’ transported in the plasma
mcl on Aortic
notadoctor on Usual interstitial pneumonitis
madojo on Genital herpes
hungrybox on Obstruction of the bile duct
jambo2222 on Lung
hungrybox on Mismatch repair
hungrybox on Hydrochlorothiazide

search for anything NEW!