The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.
castlblackFA mnemonic = Microtubules Get Constructed Very Poorly:
Mebendazole (antihelminthic), Griseofulvin (antifungal), Colchicine (antigout), Vincristine/Vinblastine (anticancer), Paclitaxel (anticancer).
A = dont confuse colchicine with celecoxib. celecoxib is a 'celective' COX inhibitor
B = ziLEUton = leukotriene inhibitor for asthma+3
submitted by โpparalpha(93)
inhibition of microtubule polymerization โ inhibitis phagocytosis of urate crystals, leukocyte activation and migration, and cell chemotaxis.