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Retired NBME 21 Answers

nbme21/Block 3/Question#9 (reveal difficulty score)
A 75-year-old woman is brought to the ...
Shrunken eosinophilic (red) neurons ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—usmleuser007(464)
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CNS Hemorrhage/ damage 1) 12-48 Hrs = red neurons 2) 1-3 days = neutrophils (liquefactive necrosis) 3) 3-5 = macrophages (microglia) 4) 1-2 weeks = Reacitve gliosis (+ vascular proliferation) 5) more than 2 weeks = Glial scar

(note: the pathogenesis is similar to MI and its scar formation; however, the time course for CNS is just faster)

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teepot123  fa 19 pg 500 +1
icedcoffeeislyfe  FA2020 pg 512 +2



 +1  upvote downvote
submitted by โˆ—visualninjacontender(18)
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the infarct occurred 16 hrs ago, from 12-24hrs after the infarct there will be Red Neurons.

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tsl19  FA 2018 - p. 496: ischemia -> pyknosis within 12-24 hours. +
d_holles  yeah the infarct occurring 16 hr ago is key. i zoomed in only on the died 1 hr later +
apurva  Me too zoomed on โ€œ1 hour laterโ€ and marked no change +



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submitted by โˆ—meryen13(48)
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https://webpath.med.utah.edu/CNSHTML/CNS048.html

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