In the great words of Dr Sattar:

"Prostaglandin E2 mediates feeeeeeeeeever"

NSAIDs --> block prostaglandin syn

Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain.These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus.. It is now clear that most antipyretics work by inhibiting the enzyme cyclooxygenase and reducing the levels of PGE(2) within the hypothalamus.

https://www.ncbi.nlm.nih.gov/pubmed/11566461

Almost failed this question but i kept hearing Dr Sattar screaming prostaglandin E2 FEEEEEEEVER