NBME 21 Answers : Block 2 : #40 = Acetaminophen and nonsteroidal antiinflammatory ...

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nbme21/Block 2/Question#40
Acetaminophen and nonsteroidal ...
Prostaglandin E2🔍

+25 upvote downvote
submitted by acanthosisnegrocans(25),

In the great words of Dr Sattar:

"Prostaglandin E2 mediates feeeeeeeeeever"

NSAIDs --> block prostaglandin syn

thisisfine This is all I heard in my head +6

temmy Me it was so weird +

peridot I do want to add, that while PGE2 is the right answer, FA19 p.213 says that IL-1 and TNF are involved as well. However, because the question asks about what is going on in the hypothalamus, the answer is PGE2. If the question had been asking about what the macrophages were releasing to influence the hypothalamus, then the answer would have been IL-1 or TNF (FA didn't specify if it was TNF-a though...). +

+4 upvote downvote
submitted by temmy(92),

Almost failed this question but i kept hearing Dr Sattar screaming prostaglandin E2 FEEEEEEEVER

+1 upvote downvote
submitted by aishu007(3),

Elevations in body temperature occur when concentrations of prostaglandin E(2) (PGE(2)) increase within certain areas of the brain.These elevations alter the firing rate of neurons that control thermoregulation in the hypothalamus.. It is now clear that most antipyretics work by inhibiting the enzyme cyclooxygenase and reducing the levels of PGE(2) within the hypothalamus.

https://www.ncbi.nlm.nih.gov/pubmed/11566461

yotsubato Ugh, again a concept NOT in UFAP anywhere. Bites me in the ass every time +3

epr94 pg213 FA2019 +7