NBME 21 Answers : Block 2 : #32 = A 17-year-old boy has the acute onset of lethargy, ...

+2 upvote downvote
submitted by pparalpha(23),

EBV (HHV-4) infects B cell through CD21.

Atypical lymphocytes on peripheral blood smear (not infected B cells, but reactive cytotoxic T cells).

"Mononucleosis": + monospot test (antibodies detected by agglutination of sheep or horse RBCs)

sbryant6 Atypical lymphocytes are CD8+ T cells, not CD4+. Remember that. +4