need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

Retired NBME 18 Answers

nbme18/Block 1/Question#19 (reveal difficulty score)
70 yo woman, increasingly severe pain in ...
Pleomorphic neoplastic cells producing new woven bone ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +7  upvote downvote
submitted by mahesh(7)
get full access to all contentpick a username

Osteosarcoma histological appearance. Paget disease is one of risk factor

get full access to all contentpick a username
spow  Looking back, I know it's osteosarcoma but the lung metastases made me think of Ewing's +
makinallkindzofgainz  Ewing sarcoma is common in boys <15 years old. This patient is a 70 year old woman. The stem notes elevated periosteum and a sunburst pattern which are characteristic of osteosarcoma. +2
llamastep1  Also "sunburst pattern" is a classic description of Osteosarcoma. +1



 +1  upvote downvote
submitted by โˆ—mamed(25)
get full access to all contentpick a username

What is the neoplastic chondrocytes filling lacunes?

get full access to all contentpick a username
mumenrider4ever  I think that's a chondrosarcoma (tumor of malignant chondrocytes, found in the pelvis, proximal femur and humerus, FA 2020 pg. 465) +1



 +0  upvote downvote
submitted by โˆ—windy48(0)
get full access to all contentpick a username
  • Although rare in the elderly,"sunburst" pattern is the textbook presentation of osteosarcoma.

  • The answer is almost verbatim from FA: "Pleiomorphic osteoid-producing cells (malignant osteoblasts)."

  • Paget's disease is a risk factor for osteosarcoma

get full access to all contentpick a username



 +0  upvote downvote
submitted by โˆ—step7777(7)
get full access to all contentpick a username

Of note, osteosarcoma also is the only bone tumor with a biphasic epidemiological distribution. More common in adolescents, but can also occur in elderly.

get full access to all contentpick a username
drdoom  also known as โ€œbimodalโ€ (since distribution shows two modes: in the second decade of life and the eighth) +



 +0  upvote downvote
submitted by saraluciachega(1)
get full access to all contentpick a username

Also, remember that Paget disease increases risk of osteosarcoma (seen in histology as neoplastic spindle-shaped stromal cells admixed with tumor osteoid and thin trabeculated bone)

get full access to all contentpick a username



Must-See Comments from nbme18

feliperamirez on He is medically qualified to drive
anechakfspb on Tubular atrophy
aneurysmclip on Endothelial nitric oxide synthase production
azibird on 24,25-Dihydroxycholecalciferol
famylife on Increased transcription of HMG-CoA reductase
match95 on Plasmid loss
apurva on Antineoplastic
cbreland on Basement Membranes
match95 on Proximal tubule: isotonic; Macula densa: ...
sugaplum on Abnormal migration of endoderm from the ...
amirmullick3 on Myelofibrosis
merpaperple on Primary spermatocyte
wishmewell on Alpha-synuclein
namira on Greening reaction on blood agar

search for anything NEW!