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NBME 18 Answers

nbme18/Block 4/Question#45

35 yo man, prolonged QT interval

Outward (delayed) rectifying potassium channel

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submitted by jorgejeje(0),

Is a case of congenital long QT, there are two principal causes; Romano-Ward (dominant) and Jervell and Lange-Nielsen syndrome, the second one related to deafness (recessive). It's important to remember the relationship of the EKG and the cycle of action potential of the cardiac muscle cell because the QT is correlated with the repolarization (FASE III), similar with the antiarrhythmics, the ones that affect potassium channels (FASE III) are more related with alterations in QT and ventricular arrhythmias.