NBME 18 Drug-related antibodies (NBME Answers)

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NBME 18 Answers

nbme18/Block 3/Question#13 (reveal difficulty score)
35 yo woman, 2 days pain in left leg
Drug-related antibodies 🔍 / 📺 / 🌳 / 📖
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submitted by ∗sugaplum(487)

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Heparin induced thrombocytopenia: IgG against platelet factor 4
FA 2019 page 427

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submitted by ∗avatar(17)

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Heparin-induced thrombocytopenia (HIT) type 2—development of IgG antibodies against heparin-bound platelet factor 4 (PF4). Antibody-heparin-PF4 complex activates platelets thrombosis and thrombocytopenia. Highest risk with unfractionated heparin. HIT type 1 characterized by nonimmunologic milder drop in platelet count, usually asymptomatic. FA2020 page 436

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avatar treatment for HIT: Bivalirudin, Argatroban, Dabigatran +1

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