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NBME 17 Answers

nbme17/Block 0/Question#0 (reveal difficulty score)
A 35-year-old man comes to the physician for ...
Dynein arms ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1780)
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This man has Kartagener syndrome, which has immotile cilia due to a dynein arm defect (FA2020 p49)

Important question parts that point to Kartagener syndrome:

  • Recurrent sinusitus and bronchitis - lack of motile respiratory cilia predisposes these individuals to upper respiratory tract infections
  • Potential infertility - he is 35 and he is married with no children (though it never mentioned he had tried for children), individuals with this defect have immotile sperm and thus reduced fertility
  • *Point of maximal impulse at the 4th intercostal space on the right - This is indicative of *situs invertus which is heavily associated with Kartagener syndrome. This is probably the "buzz" for the question that should point you to the diagnosis and therefore answer
  • The nasal polyps with squamous metaplasia are also associated with Kartagener syndrome
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