This man has malignant hyperthermia, a rare but life-threatening complication of some anesthetics (particularly the volatile/inhaled) (FA2020 p550)
The treatment is dantrolene, a ryanodine receptor antagonist which decreases calcium release from the sarcoplasmic reticulum (Dantrolene is also used as a treatment for neuroleptic malignant syndrome).
If you want a refresher on what the heck a ryanodine receptor (RYR) is: (FA2020 p456)
In skeletal muscle, the RYR is the calcium channel on the sarcoplasmic reticulum which is coupled to a voltage sensitive dihydropyridine calcium channel.
In the heart, dihydropyridine receptors are also called L-type calcium channels or Long-acting. T-type are a completely different channel and are transient (respond to lower voltage). RYR are still RYR but a different subtype than in skeletal muscle.
submitted by โcassdawg(1781)
This man has malignant hyperthermia, a rare but life-threatening complication of some anesthetics (particularly the volatile/inhaled) (FA2020 p550)
The treatment is dantrolene, a ryanodine receptor antagonist which decreases calcium release from the sarcoplasmic reticulum (Dantrolene is also used as a treatment for neuroleptic malignant syndrome).
If you want a refresher on what the heck a ryanodine receptor (RYR) is: (FA2020 p456)