She has Mycoplasma pneumoniae which causes walking (atypical, interstitial) pneumonia and increase in cold agglutinins (IgM)
FA2020 p150
If you are a sketchy person (which I am not), I am pretty sure Mycoplasma is depicted in the cold, or as a guy on skis in drug ones, which can help you remember cold agglutinins. Also Mycoplasma -> IgM (the letter M).
Also (for immuno nerds or rationalizers), IgM is the first antibody to be produced so it would make sense that you would have IgM this early in the infection which can cause cold agglutination (she has only been sick for a few days). IgG causes warm agglutination, which is typically seen in more chronic processes like SLE and CLL (FA2020 p423). No idea if that is the actual mechanism but it is how I keep them straight in my mind and makes sense.
flapjacksAs a "sketchy person" and not a "rationalizer", I can confirm the Mycoplasma has red blood cell "pucks" agglutinized
with IgM snowflakes+27
j44nJust to add, she has interstitial infiltrates so its an atypical pneumonia, no other kind of atypical pneumonia would cause them to have agglutination. I'm not a rationalizer I'm a massive over thinker+2
sexymexican888Yeah, im a sketchy person too! Side note, for autoimmune hemolytic anemia I remember it this way: IgM -> Me Cold, go INSIDE (cold agglutination, intravascular hemolysis) IgG -> Go outside its HOT (warm agglutination, extravascular hemolysis) +8
submitted by โcassdawg(1780)
She has Mycoplasma pneumoniae which causes walking (atypical, interstitial) pneumonia and increase in cold agglutinins (IgM)
FA2020 p150
If you are a sketchy person (which I am not), I am pretty sure Mycoplasma is depicted in the cold, or as a guy on skis in drug ones, which can help you remember cold agglutinins. Also Mycoplasma -> IgM (the letter M).
Also (for immuno nerds or rationalizers), IgM is the first antibody to be produced so it would make sense that you would have IgM this early in the infection which can cause cold agglutination (she has only been sick for a few days). IgG causes warm agglutination, which is typically seen in more chronic processes like SLE and CLL (FA2020 p423). No idea if that is the actual mechanism but it is how I keep them straight in my mind and makes sense.