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NBME 17 Answers

nbme17/Block 4/Question#3 (4.3 difficulty score)
A 46-year-old man is treated with oral ...
Suppressing the early response of T lymphocytes to activation🔍

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submitted by cassdawg(548),

Cyclosporine is an immunosuppressant that blocks T-cell activation by preventing IL-2 transcription (FA2020 p120)

Even without remembering the mechanism of cyclosporine, the answer could be inferred as most medications used after kidney transplant (cyclosporine, tacrolimus, sirolimus, basiliximab) block T-cell activation. This mechanism MAKES LOGICAL SENSE because T-cells are the primary mediators of acute rejection, which is what we are trying to prevent directly after a kidney transplant.