Glucocorticoids inhibit Nfkb, suppress both B and t cell function by decreasing transcription of many cytokines. Induce T cell apoptosis FA 2018 P120

The prednisone will induce T cell apoptosis (FA2020 pg 120)

I also looked at it this way: Crohn disease is T-cell mediated (noncaseating granulomas). Major factor in the promotion of granulomatous inflammation are CD4s, which you would want to inhibit.

cortisol

Inhibits WBC adhesion leading to neutrophilia which means it alters neutrophile function as well

man sometimes i think nbme is out to get me :/