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NBME 17 Answers

nbme17/Block 1/Question#48 (5.6 difficulty score)
A 9-year-old girl is brought to the physician ...
Diverticulum of the roof of the embryonic oral cavity🔍

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submitted by cassdawg(580),

She has a craniopharyngioma, the most common childhood supratentorial tumor which is derived from remnants of Rathke's pouch (FA2020 p528). Craniopharyngiomas commonly have calcification and can cause hypopituitary issues (like low HGH). Suprasellar is also the location of the pituitary, and pituitary tumors in general cause bitemporal hemianopsia due to compression of the optic chiasm.

Rathke's pouch (where craniopharyngiomas and anterior pituitary are derived from) is derived from the surface ectoderm of the oral cavity.

Note that the neurohypophysis (posterior pituitary) is derived from neural ectoderm while the adenohypophysis (anterior pituitary) is derived from surface ectoderm of the oral cavity.

waitingonprometric  If you can recognize that this is a craniopharyngioma based on "calcified cystic mass in the suprasellar region," then you can think "cranio-" mass in the brain, "-pharyngioma" from structures connected to the mouth. Always works for me! +3  
cheesetouch  FA 2018 P512 +1