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NBME 16 Answers

nbme16/Block 1/Question#24 (2.9 difficulty score)
A previously healthy 52-year-old man is ...
Binding of antibody to the acetylcholine receptor🔍

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The stem is describing myasthenia gravis: ptosis, fatigue with continuing exercise, slurred speech, etc.

So, there will be autoantibodies to the ACh receptor

In contrast, LES gets better with activity. There are autoantibodies to the presynaptic calcium channel and decreased ACh release