invite friends ⋅ share via emailtwitter
support the site ⋅ become a member ⋅ unscramble the egg
free120  nbme24  nbme23  nbme22  nbme21  nbme20  nbme19  nbme18  nbme17  nbme16  nbme15  nbme13 

NBME 16 Answers

nbme16/Block 3/Question#3 (4.1 difficulty score)
An 83-year-old man comes to the physician ...
Bullous pemphigoid antigen🔍

Login to comment/vote.

The stem is describing bullous pemphigoid, which produces IgG antibodies hemidesmosomes. (PV is IgG antibodies aginst desmoglein-1 and desmoglein-3, in the oral mucosa).

BP produces the tense blisters that have a negative Nikolsky sign (don't rupture with rubbing). This is because they're supepidermal. Surprised they didn't ask about hemidesmosomes, but I think that that the BP antigen is part of the hemidesmosomes and recruits the autoantibodies.