p53 protein is the quintessential tumor suppressor (it activates apoptosis). HPV carcinogenesis is caused by insertion of the virus into host DNA that produces a protein which binds to an essential p53 substrate, functionally inactivating p53 and preventing its apoptotic cascade. Transactivation/TAX is how HIV and HTLV cause cancer. c-myc translocation causes Burkitt lymphoma.
submitted by โbwdc(697)
p53 protein is the quintessential tumor suppressor (it activates apoptosis). HPV carcinogenesis is caused by insertion of the virus into host DNA that produces a protein which binds to an essential p53 substrate, functionally inactivating p53 and preventing its apoptotic cascade. Transactivation/TAX is how HIV and HTLV cause cancer. c-myc translocation causes Burkitt lymphoma.