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hungrybox
Great explanation! So frustrating that I got this wrong, should have been easy.
+4
temmy
the way i thought about it was how did the neutrophils get there? the answer is via increased vascular permeability
+18
nor16
they, unfortunately, did not ask " how did neutrophils get there"
but " whats the cause of the swelling "
not to confuse with " what causes the swelling "
+2
divya
absolutely right temmy. that's how i thought about it too.
+1
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joyceeepan
the way i though about it was: you need antibodies (IgG/IgM) to activate the complement system. But there's no such a thing as an anti-gout antibody. (and it is not an infection neither)
+3
an_improved_me
Thats not exactly true for a couple reasons. I saw a UWorld question that said something along the lines of an ApoProtein being useful b/c it binds the urate crystals, and makes it less likely for the crystals to be opsinized/recognized by neutrophils. Therefore, Abs do play a role. Secondly, you can have activation of coplement via the alternative pathway, which does not require ABs.
+2
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zevvyt
yes. Histamine causes vasodilation and increased vessel permeability. But it's not involved in Gout. Gout is more about Neutrophils and Macrophages activating eachother and not really about Mast cells.
+5
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submitted by โneonem(630)
This is a case of acute gout. Monosodium urate crystals are taken up by neutrophils, leading to an acute inflammatory reaction. T-cells aren't really involved in gout (more rheumatoid arthritis).