NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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umdqa-ebiidtneiUti lyosstoriep is otn syrrievlbe facefetd by us.iilnn Teh soequitn assk fro reisevrble wasy htat inlnsiu fetfasc ti, nda qibnuiaioniutt dulow adel ot egatdairodn vai rse,eaopst hcwhi is ton bve.lseirre taamyculc/Nipcserol tiguhsnn eakms esnse aucseeb FOXO is a nornitrcptisa frt,aco os it ant’c od its jbo fi ti is ni eth !salcoyptm

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meningitis nahTk uyo fro royu ial!eptonxna On e ut:qieosn owH tubao het rsenie lonhophai?trpsoy sI ti nwaseerd by preu trioinmamzeo thta eth FOOX FT si iseern potrhdolha,spey ro si ti a neaegrl ftac hatt lal sTF' rea tnh-ieensirnereo heolpdtohypra?s +

tsl19 I'm nto ues,r utb ti mya be as mslepi sa :this ue-emutabdiidiqtni pooryitsels is esl,vireerbri tbu tobh N/C lntiugsth nda rolaoposithhypn era elnleyrag sevrrilbee .esrspsoec +

didelphus I sola edeugss atht OOXF smut eb a prat of the IPK3 aa,thywp cneis isunlni atlegesru soemmiatlb toguhhr 3PIK adn teh nuteisqo mets acpflclyisei tnsmineo atth. hoalpiPysohtorn si a joarm rpta fo tath ata,hpyw so neev eiltnrydci rpalooyshhptoni oluwd gateuler XOFO. sgrauritFtn tiseq.uon +21

niboonsh y,se OXOF si cdetfafe rsewadmtno fo eth aiaitntcov of 3P.IK hisT is a lrlaey godo diveo ttha expslani hte oelhw ceadasc umycswgo.4/h/d:ptva=twLtwc9tewsbu-?.3weo/hN +2

alexb ocgicArdn ot wdiieakpi (/.p/nhiopstkF.O:ewXdiiOk/tiirg/1eaw) lotrooiahnhpysp fo OOXF1 is .iebierrlersv sTih is rnirefgre to tyrhoioonahplsp of seinre erussdei on XFOO yb Akt, wihhc urscoc in osnreeps ot lsn.inui uBt het BMEN nwreas usgtsegs its' reervbeis.l s'ahWt up? +2

almondbreeze cudlo iwik eb orgnw no tnhaooiylpphsor negib evlrrs?rbiiee rgdncoiac to ihts ie,lrtca it si a ebsevrreli re:spocs egnuirolta fo FOox irorsnnicttpa ftocars yb vbeesrlrei npohoatipoysrhl adn cetanloitya (co13/:r610e0eaetp#/lr0.n490esct/msed1/s8/snc8ii7ceiSi1hwc0.5w0cicwti70t/ps oem) wiik oi,nf ho,veerw si hflulep : nI its ohldnaohspye-rutp ets,ta OXOF1 si liodlacez to the ,lcuunes weehr ti bdsin to eht ninuils peoessnr esencequ atodecl in eht rpeoortm for ucesglo tp6aephhs-sao and cnarisees sti rtea fo tnsnrtpaiorc.i X,O1FO grtuhoh niasinercg trtirpcnonsia fo -ecs6hsppu,hat-ealsogo ediltnicyr nseaseric eht tera fo icpeaht gcueslo 9cr.1uoi[pndot] ree,vowH hwne OX1OF is srptadeohophly by tkA on ,r4h-2T 5e-62,Sr adn -31r9,eS it si uededxcl from het ne,slucu hewer it si nhet taidieutinbqu nad dgredad.e hTe poployhthairosn of 1OOXF yb tkA seteysubqlun credsaees the ithepca cousleg pnitcrooud uothrgh a drceseae in tianprnsirotc fo olgecsu hseppt6h.aa-os +

leaf_house tI sseme like the nroppohhlsyotai omfr tAk adsel to d,ioercsutnt btu emyab hte sntospiuam is hatt tath thhonrspoiyolap ptes gxu(lcedin rveye herto pest fo mnistuuoo-ptibeiqroe w)hapyat si ,leverirsbe rweeh lpssytoiore is a.nlfi hnsno@o bi vdioe si doog tub odts'ne isptl hsit .oen +

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submitted by ∗imgdoc(183)

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shTi untesoqi si isngka ubota het innisul erocrept ystnreoi eiakns .tyhaapw So eakt it romf rtee,h

ehT opophnyrlhaosti of the IRS saitcteav a nglasi ruttansodcin cadasce htta ldsae ot eht itainovcat fo teorh isnekas sa lelw as siancrptnirot atrcsfo thta meaedti teh rratueliclnal fcsfete fo inuni.sl laNteclroapCcyusmi/ nliuthtsg - sye rbe)rve(leis
ei/rernneSoeinhT snesaik rea oasl nkwno to crduee eth tivtyiac of iunil.ns - esy l)eeisev(rbr
nUbiqiuti - itmdeeda oseoyrplist - no on(t rlbvi,)ersee and saol nlisiun callyoliatebm iceanrsse potrine thsynessi so ti eno'tds match waht snluini does .sanwyay

octrrec me if 'Im .gwnor

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usmle11a i tiknh oyure orcrect ascue uiuiitnbq deietmda rooeytlips si na everlsbirire sep.t +1

+7 upvote downvote
submitted by ∗hello(429)

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heT Q stem sastte OFXO si a osipntcrinrat tcfroa that onrspeds ot nniilsu saninggil yb ltargnie eht iroantntirpsc of tmaieolcb ngees g;&t-- feterr,eoh FXOO is a aoircnptrtins arctfo ovednlvi in osmbm.aielt This hosldu kaem sseen beseuca erntpliunis-ocer onttiiavca hsa a lore in egitalgrnu io.stmlbmea

hTis Q kssa obtau veseerirbl yasw that nilnsiu uearegts XOOF rtsonanipctr fotrac ay.vitcit

i-uiebiaqtidnUmedt repliosstoy is rsverbeiilre. iaEmteinl lal chocise ecpetx fro ,B D, dan .H

noers-tricpInluse fciunnto touhhrg K3PI nnalg.iisg 3KIP nnsialigg nlvoseiv shrpalthioyonpo of eernsi -;g&t- ireens lhrsapoyiophtno is a elersevbri ers.spoc aiilnetmE .H Y:FI oemnrpotni/ai dcia orlyaphohpnotsi is wylaas ebrelvers.i

uYo are tefl hitw ciesoch B nad D.

XOFO is a cionirsnrtatp artcof ;-g-t& iosptcnrtinra toafscr amidtee eneg atictvyi yb stlhuitgn twebene teh lmptcosay nad slun.uec ngiuatRgle the ooactiln of OOXF snctiiroaprnt oftarc .ei.( lctsyapmo .sv usnue)lc ilwl fheeetorr veyiserbrl muoeldat iemFddte-aXOO toceaiblm eegn iat.vtcyi

Thsi slveea uoy with het crrtcoe awsne:r ceiohC .B

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adong A ettreb ayw ot nhtik otbua it is iulnnis stca hthuogr AMPK iwhch is a serinteoennireh/ nkeasi +1

amy I tertiaepnetd yrl/ctCNisealaumocp tshnlugti uldow eb eht lseutr fo eienrs ,hoystrlaooiphnp so hte vrbeerlise iamocftniodi is oynl on neiser apio,hphltonyros hwhic dlae to /occasrnecliyalpumt sin,hguttl utb hte uhstgltni fsliet si tno nuerd Iditnicm.iofo a tgo ti rgow.n +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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nreeiS tooproayihnsphl lliw dreecu i'sinnsul e.ftfasc tI ctas no eth noistery .eaiskn

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alexandramda c99-ygwe/8i.w09bflc0S0mlh3od.sw-2/e)/l086pp07tcf2.otur0p/-ndor/t:( +

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