NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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iuUabqdet-tdmiiien prsyeoositl is not rlyvbsieer edceafft by nsiiul.n ehT uisoqetn kass for revielsber wyas atht sliinnu tfcfesa ti, nda unttiuoaibiqin ouwdl eald ot digodrtaaen iav ta,soeerps cihhw si not leeribsvr.e ilaeNacolmuyccrt/sp nnhgtuis aekms esens bescaeu XFOO is a pstinacrriton frca,to so ti ’tanc od tis jbo fi it is in eht satoplcmy!

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meningitis akThn uyo fro yoru axi!nnletopa e nO :enoqtsiu Hwo uoatb the ensire il?ohhpsrpnyotao Is ti danrewes yb eurp aimzetnoomri ahtt het FXOO FT is nriese tyooedphlpa,rhs ro si ti a ergeanl fcta ahtt all Fs'T era nrienehto-siener eph?soylrtaophd +

tsl19 'Im otn uesr, ubt it aym be sa pismel sa hsit: nmiiutatbdee-uiqid stoysreploi is elrebev,rriis utb htbo C/N ustlngthi dna asotnhihyproplo aer gyareelln ervbelresi ocsepsse.r +

didelphus I alos dgussee tath XFOO tusm be a part fo eth KI3P ptay,wha scnei iniusnl esgleatur tiamlbmsoe tuhorhg IKP3 nad het ienuoqst setm ysipfeaclcli ietnmsno at.th spirPyotooalnhh si a jramo trap of atth ,ypawhat so nvee reiicndlyt itysoolnphhprao loduw elretgau XO.FO nttigFsraru uiq.tones +21

niboonsh s,ye FOXO si eaftecdf dsmatorewn fo het ttniaciavo of .3IPK ihsT is a aylrle gdoo eiovd hatt lnipxaes hte welho dsaccea ow/h.cub.awLvuN3/wcyes?t-wp/4h:dotm9stwteg= +2

alexb onAccgrid to aiidkpewi (OhtsO.powFaieiriwek/:/pi.ndXt/g1k/i) rayostonphohipl of OOF1X si elvriebsirer. sThi si fgrireren ot aphitoroynhospl fo eerins eirdssue on OOXF yb kA,t whihc oucscr in senproes to niulni.s tuB hte BMEN wnears tsssgueg it's evreiel.sbr 'athsW ?up +2

almondbreeze uldco iwki eb owgnr on lsopootanhyirhp nebgi rer?reiselibv dgoinrcca to hist lie,acrt it is a elvsrrieeb co:epsrs gaoltuneir fo FoOx prcionsrtntia otfascr by srlbeievre rthpniyaoospohl dna otetanlyica (ecp0ti1ew405cio/1S0ccc#w1eli.s7/0ndm7e9t8s:w/8tsi/phecr/i.06ritc0sna103e/me )os wkii ,nfoi hrwv,oee is hpfuell : nI ist poph-anuetslryodh tt,sae FXO1O is alzcideol to the ,uuenlcs ehrew ti sbidn ot the niusiln ronsespe ucseeeqn ceoaltd in het rrtmooep orf seoclug tp6poshehs-aa adn eirsaecns ist trae fo iitors.pntcnar O,OX1F hotruhg iangriescn nritratspcino of aotospgepe,sl-s6hu-hac dneitirycl nsricease eth trae fo theicpa sgoluec p1.[rd9io]ocunt Heevrw,o nhew XFOO1 is dphloeaohysrtp yb ktA no hr4-2T, erS,-256 nda 1Sr3,9-e it is xedeucdl mrfo eht slc,unue eehrw it is thne uiduaenbqttii adn redgd.ade The poiplhntshooyar of OO1XF by ktA bqutseuensly reesecsda eht iceptha ucglose doropicntu gohrhtu a edscaere in ntrnocpraisit fo losugec oaehap-sth6ps. +

leaf_house It mssee leki the tpihrpnlyaosooh omfr Atk elasd ot undrttces,oi tbu eymba hte spasnutmio is that htat haonhptposyrilo pste xlguedi(cn eyerv oethr stpe fo permio-unoeqttbiuosi apy)awth si lbvres,iree rhewe eioplotsrsy si fnlai. sni nhboo@ vodie si dgoo utb dtonse' stlpi htsi .oen +

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submitted by ∗imgdoc(183)

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hTis uionseqt is ksngia atuob teh siunlin tocerrep tnroyeis iasken aa.thwyp So keat it ofrm the,er

hTe yhalpoiotnpsroh fo teh ISR isaavctet a lgsian sturnnitodac cdaeasc tath lsaed to het antvtciaoi of orthe ikassen sa lewl sa paoctnisnrrit fosctra atht madteie eht railaurlcteln ecffset of n.lnsuii oCsaiulrectypm/lcaN tntsuiglh - sye )rvs(ierlbee
eiirTnnhSn/reeoe asenkis aer salo nokwn to ucedre the iyvtitca of in.uslni - sey l()bersivere
Utqibiniu - iademdet isyptolreos - on o(nt rbr,sleve)ie nad oals iilnusn lalmielbaocty esaseincr rtneipo issnetyhs so it setdno' hactm ahtw snniliu osed synwaay.

cercrot me fi 'mI .ngwor

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usmle11a i iknht uyero errcotc sceua uitqbiiun atdedmei lpityeoors si na revelibersir .epts +1

+7 upvote downvote
submitted by ∗hello(429)

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The Q semt satest FOOX si a tctiairnrsonp rtofac htat sderospn to snniuil ngnlgsiia yb iltagnre eth nrctaiitnorsp fo aecibtlmo eengs -t-&g; rftoe,rehe OFXO si a casotinrtinpr cratfo olvedvni in smaib.tlmeo ihsT hldous emak nsees ebucsea oenpsuie-tnlcirr vtiinocaat has a erlo ni inalggreut smlbia.meot

shTi Q akss toaub iblresevre awys taht innsilu etaugsre OFXO rarcsnonpitt foctar av.tiycti

iidqebttad-muUieni eorsyltpsoi is eirveireblsr. ilamieEnt lal hcisoec txpcee orf ,B D, and H.

etrpsusrlIc-onein fintnocu gthrouh IP3K lisg.nniga KPI3 sninailgg evslvnio aolripyohpthosn fo iserne g-;t-& irnees arltpnhihoospoy si a slreibreev .pcsrseo anEmlieit H. FYI: oinrne/otmpai dica noothspoihaylpr si awasly iebev.srlre

ouY ear elft ithw icocseh B dna D.

OOXF is a rnirctosnpait tfaorc ;&t-g- csnrtaornpiti casfotr emteida geen tatciyvi yb ihutltgsn ebenetw eht plosatycm and u.eunlcs eiRguglnta teh nitacloo of XOFO nnartoriitpcs cafrot i..e( maoltsypc .vs u)nulces liwl eoertrfeh vylbreseri ldmueoat md-ieFtdXaeOO eoiamlcbt egen ttviiya.c

ishT ealsev ouy htiw eth ceoctrr n:awesr cCeoih .B

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adong A rtetbe way to tiknh boaut it si iusninl csta hgohrut KAPM hhciw si a oenrres/ineeinht seinak +1

amy I nptateertdei loypsiNltucrecaamC/ utgthinls ulowd eb het utslre fo enesri ypsaohhrioopnt,l so eht sbeirelrve anfimtciooid si ynol on niesre h,pootoynhsirpla hiwch elad to llpyaicce/omcausrtn it,lnutgsh btu hte thtunilgs fsitle is not nrdue Ia.dfmicoino it tog ti .ongwr +

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submitted by ∗usmleuser007(464)

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eSnrei nohphlaiotsrpoy ilwl uecerd usnisil'n acft.fes tI asct on the ietrnosy kns.aie

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alexandramda 2po/2yli/8-0p9e0.m9lf/.0-p-et)wc/drhl78.d9/:c3rfSwgcosutobt(w0006n +

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