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Retired NBME 25 Answers

nbme25/Block 2/Question#8 (reveal difficulty score)
The breakdown of dipeptides and tripeptides ...
Intestinal mucosa ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(23)
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Didpisepet nad pttpesiired are orcdupde yb teh yatciivt of ptyisrn nad sycyitmohrnp wtnhii eth mnuel fo eht domeunu.d reFe ainmo cadsi era udopedrc poun frtuerh iegdtsino of heest malls seditepp hwtiin eth buhsr odberr of eht seniittaln o.amsuc

eTh mnuel fo teh euunmdod si gwrno esbueac that is herwe lragre elpxcmo dlieepotpsyp era bnerok dwon to di- adn idpeptrsite utb hte ntioac fo natkig i-d nad ietdistprpe ondw to nudidalivi nimoa siadc ephpnsa ni the saiilntetn .scomua

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Maybe a way to remember this would be to think about Hartnup disease, an AR deficiency of neutral amino acid (primarily tryptophan is implicated) transporters in the proximal renal tubular cells and on ENTEROCYTES. This leads to neutral aminoaciduria and decreased absorption from the gut and little breakdown of dipeptides and tripeptides to amino acids in the intestinal mucosa. Decreased absorption from the gut causes decreased tryptophan for conversion to niacin and pellagra-like symptoms (diarrhea, dementia and hallucinations, and dermatitis in the C3-4 circumferential "broad collar" or "Casal necklace" dermatome, hyperpigmentation of sun-exposed limbs).

So if you can't convert dipeptides and tripeptides to amino acids in the ENTEROCYTES in the INTESTINAL MUCOSA, then you can get Hartnup disease.

+1/- shak360(23)

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