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NBME 24 Answers

nbme24/Block 3/Question#26

A 54-year-old man with a myocardial infarction ...

Decrease in intracellular ATP concentrations

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submitted by neonem(263),

General theme of pathology: hypoxia impairs oxidative phosphorylation --> less ATP --> less Na-K pump activity so sodium builds up in the cell, causing swelling. This is the first step. Then you'd get the calcium buildup in the cell and eventual anaerobic glycolysis, causing lactic acid production and lowered pH... but this happens later and isn't the direct cause of cellular swelling, which is what the question is after.