NBME 24 Answers ↦
drschmoctor
Neutrophils sequestered in recipient lung are triggered by donor antigen (e.g., anti leukocyte IgG), which causes release of cytokines, inflammation party in the lungs.
+4
2020-02-17T23:03:32Z
hayayah
Yes! Allergic/anaphylactic blood transfusion reaction is within minutes to 2-3 hours.
(pg 114 of the 2019 FA has a list of them ordered by time)
+7
2019-06-04T22:05:42Z
hayayah
(also allergy / anaphylactic presents with more skin findings (urticaria, pruritus)
+6
2019-06-04T22:06:51Z
seagull
The time through me off too. I though ABO mismatch since it occured around an hour. I thought TRALI would take a little longer.
+7
2019-06-07T15:56:17Z
charcot_bouchard
Guys anaphylactic reaction to whole blood doesnt occur much except for selective IgA defi. so look out for prev history of mucosal infection. And it can have all feature of type 1 HS inclding bronchospasm.
+5
2019-06-26T12:01:48Z
soph
I saw hypotension and though anaphylaxis........ -.-
+
2019-07-30T00:36:27Z
usmile1
Chest Xray showed "bilateral diffuse airspace disease". This is much more indicative of TRALI than anaphylaxis which would have wheezing and possibly respiratory arrest but no actual damage to the lungs. Additionally there was no urticaria or pruritus one would expect to see with anaphylaxis.
+5
2019-09-04T01:44:16Z
submitted by brethren_md(88), 2019-06-02T18:35:38Z
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