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nbme23/Block 4/Question#8

A 36-year-old nulligravid woman and her 40-year-old ...

1 of 50

A 36-year-old nulligravid woman and her 40-year-old ...

1 of 50

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humble_station
Because p = 99/100, you can just make it 1. Then just do 2 x (1/100) and you get 1/50
+3

humble_station
Because p = 99/100, you can just make it 1. Then just do 2 x (1/100) and you get 1/50
+

unhappy_triad
Carrier frequency= 2pq
AR disorder that occurs in 1 in 10,000 the square root of 10,000 is 100
so, q=1/100=0.01, p= a number close to 1, just use 1.
plug it in the equation 2pq= 2(1)(0.01)=0.02=1/50
+1

submitted by seagull(714), 2019-06-04T00:38:11Z

Hardy-Weinberg equation = 1= P^2 + 2pq + q^2

P^2 = 1/10,000 = 1/100

Then remember P + q = 1 ------> 1/100 + q = 1 (q = 99/100)

Lastly plug back into Hardy-Weinberg Equation as:

2pq = Heterozygote carrier

(2 x 1/100 x 99/100 = 2/100 = 1/50)