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nbme23/Block 3/Question#25 (31.3 difficulty score)
A 43-year-old woman undergoing chemotherapy ...
Preformed IgM antibodiesπŸ”,πŸ“Ί

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submitted by yotsubato(1041),
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nsnTofusira rostcneai rea medatdei by pTey II yepniythisirtevs anoc.rtsei sThee uccor ued to pofrederm nbodeastii tath nbdi to het igfenro egnniat B(A pgoru on )CBR dna dlae ot hioysemsl by NK scll.e shiT is a mrof fo bnioAtyd nededtpne ualeclrl tioiyxyoctt.c

focus  Exactly! And among the blood transfusion reactions, per FirstAid: allergic/anaphylactic reaction: type 1 (we would see urticaria, wheezing, etc. Seen in IgA deficiency.) febrile nonhemolytic transfusion reaction: type 2 (host antibodies against donor HLA and WBCs) acute hemolytic transfusion reaction: type 2 (ABO blood incompatibility) TRALI: its separate category (donor antibodies against recipient neutrophils and endothelial cells) They specifically told us ABO incompatibility (despite the respiratory symptoms that could indicate TRALI) so we know this is an acute hemolytic transfusion reaction. +2  

submitted by axsa19(9),
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BA si eht loyn odbol gorpu that seod ton aevh frdormeep gMI iobeisndat in hte apasml.

oBodl gopur A hsa inatB- IMg

ooBdl rpogu B sha a-iAn MgI

odoBl orgup BA "ANA"D

Bdolo ogurp O sah hbot n-Aiat p;&ma a-nBit gMI

FA 0217 pega 309

axsa19  anti* +  
noname  FA 2018 page 400 +  
vulcania  FA 2019 p. 397 +1  
destinyschild  blood group O also has IgG, which is significant bc it can cross the placenta and cause hemolytic anemia in a fetus +1