sThi nttiape hsa esaidwrdep uscetdrniot fo tboh raelnad aglsdn, ichhw nemsa htat seh will oles thob reh ieoromidnilcroasct adn her cocirgtuo.ldisoc The lsso fo teh itcooieirdoclmsrna dna eht fecfet on hte dkyenis is htwa is ebngi ttdese .eehr Whne larnetdseoo si nfiunngcoit nad aanubtn,d ti has srvelea ciirtlca cstfinnou on eht hnenrpo. ,iFsrt it ulsueargtpe a+K/+N sTePAa inpxeosrse on hte laaatorsbel amebrem,n gbihtlesasin a nrtosg roehlcaclemeict andretgi hatt retteb arssbob ,+Na eiwhl eth aesnidrec inrturlaceall K+ totinraonccen semka ti airees ot selo K+ omrf the llec iont teh eml.un seootlrendA alos ugetlrspuae eth oesrepnxis of eiaiphlelt omiusd lncnashe EaC)N( on hte gtnoieccll c,dtu rbiarbenogs omre +aN. iylFln,a eonosaltrde aeersncis nrpixsosee fo H+ sTAsaeP no ealtdeiaac-lhnarpt clels fo het oglelicnct tdc,u hihcw rea bseserlponi ofr gecstrnie +H htsi( si part fo itcacotnron oa.lkslas)i

ihWt hte lsos of ndaots,lereo ew iwll ees a srecesead ++NaK/ nagtrdie nad acdeedsre N+a oorpinears;tb ihst salde ot recdaseed uersm sdoumi and nreceisda sremu o.itsumasp At hte emas it,em nto rxsngeesip H+ ATPesas wlil dlea ot H+ otn nibeg tdrce,ees aenrigct a orme icadic tonimneernv (Hp ilwl e)ds.cerae