shTi tnteiap ahs aederdsiwp ricsttudnoe of obht rnaldea ,naglds whihc ansme htta hes wlli lose bhot hre trioorldoiamscneci nad rhe crcl.uotiooigscd eTh slso fo teh etsciorocadomrilin dan het ceffet on hte indysek si waht is ienbg ttseed erh.e enhW arelotoesnd is itfincngnuo adn nnuatb,ad ti hsa vselrae litacric ntuconsif no eht p.rhenon Firt,s ti guptluerase N++Ka/ ATesPa oeprsinesx no teh elbatorasal a,nbermme ngaehsbltiis a sotrng hieormeccellcat egnadirt taht btrtee rsbsoba +Na, wlehi hte acisdrene rellautarncli K+ tocenntairnco makse ti rsieea ot lsoe K+ ofrm teh elcl tnio teh enlmu. nreoAeldots osla rsagleutpue eht esrxponise of ipehtlleia udimos anceslnh E(NC)a no het cngclotlie tc,ud gsbebrioarn omer N.a+ lalyi,Fn tleoadsnoer ciaseerns rexoiesspn of +H seTPasA no tld-rtclapniaaheea ellsc fo hte cgctlielno t,udc hiwch rae pilssbornee ofr encgetris H+ iht(s is tpar fo ntioocnactr iola)ksals.

ihWt hte sslo fo oerlton,ased we illw see a csedseaer N++a/K trgeadin and cedeaesrd a+N ;ebrprotsinao hsti sldea ot deredsaec smeru udmosi adn cednaresi rumes .soimuptas At hte sema et,im ton reinsepxsg +H APasTse liwl ldae ot H+ not inbge ereeds,tc enacitgr a oerm icdiac onvrmtienen p(H llwi eecdrse.)a