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NBME 23 Answers

nbme23/Block 2/Question#50

A 65-year-old man recovering from a cerebral ...

Preventing ADP-stimulated platelet activation

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Clodipogrel prevents platelet aggregation by blocking the ADP receptor. The ADP receptor is what is responsible for putting GpIIb/IIIa receptors on the surface of platelets. Without GpIIb/IIIa, the platelets cannot aggregate together.

paulkarr  Just adding that Clopidogrel irreversibly inhibits the P2Y12 receptor. This can be found in FA2019, pg 403. The other drugs in this category are: Prasugrel, ticagrelor, and ticlopidine. Ticlopidine is famous for causing Neutropenia and having an increased risk for TTP. +