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NBME 23 Answers

nbme23/Block 2/Question#34
A 35-year-old woman comes to the physician ...
Synthesis of viral DNA🔍

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submitted by gh889(66),

Referring to NRTIs and NNRTIs as mainstay of treatment

Mainstay: efavirenz (NNRTI), tenofovir (NRTI), and emtricitabine (NRTI)

ususmle  I guess he is asking about integrate,,,,, where his should be integrated into host dna to get replicated .. triple therapy includes. 2drugs NRTIs and other one is integrate +  
whoissaad  @ususmle NRTIs would still inhibit DNA synthesis since they mess with the reverse transcriptase which is needed to make viral DNA. +2  
thotcandy  @ususmle HIV triple therapy is 2 NRTIs/NNRTIs + 1 protease inhibitor. Plus, if her CD4+ cunt is already 60/mm, that shit is well integrated in her CD4 cells already, right? +1  
brotherimodu  I was confused because isn't HIV an RNA virus? +  
focus  @brotherimodu yes and therefore it uses a reverse transcriptase +  



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