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NBME 21 Answers

nbme21/Block 4/Question#46 (40.1 difficulty score)
A 14-year-old girl is brought to the ...
TP53 🔍
tags: Li_Fraumeni p53 process_of_elimination 

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 +4  upvote downvote
submitted by neonem(500),
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sudoSn ielk a easc of -FniemruiaL rnsdomey - enics 5p3 si a mruto uspreosrsp ofr a uchnb fo cell ,tpsye sonitumat ni htis egen a(s ni FLS) turels ni a miyadr fo liiamalf rmuot py.tse

pparalpha  Li-Fraunemi syndrome = SBLA (sarcoma, breast, leukemia, adrenal gland syndrome) and occurs because of an autosomal dominant inherited mutation of p53 APC: linked to FAP (colorectal cancer) RET: linked to papillary thyroid cancer, MEN 2A, MEN 2B RB1: retinoblastoma +9  
privatejoker  The thing that threw me off was that the only connection in her FH to the above SBLA reference was the mention of a paternal cousin with adrenocortical carcinoma. The other two mentioned had brain cancers, which seem completely outside the scope of the above mnemonic. Then again, as mentioned elsewhere, I suppose the best policy on these is just to rule out the absolute wrong answers. I swear, the NBME is lying when they tell us to choose the "best" answer on some of these. What they actually mean in practice is for us to choose the least shitty. +14  
dbg  ^ this guy cracked the code. nbme ur doomed. +4  
cienfuegos  @privatejoker: I feel the pain. Quick FYI: UW includes brain in the associated tumors. +3  
hyperfukus  we can just make her thing SBBLA and hopefully never get this wrong again +7  
jakeperalta  @privatejoker: according to UW, Li Fraumeni includes SABBB(sarcoma/adrenocortical/breast/brain/blood(leukemia)) +2  
ac3  side note: RB1 = retinoblastoma with an increased risk of osteosarcoma +  
lukin4answer  TP53 associated with SBLA + Brain tumor + Anaplastic Thyroid ca + Transitional cell ca. -UW +  



 +2  upvote downvote
submitted by hayayah(983),
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tMos amhnu cacnser aer dt/ a sosl of nnuoftic fo 53TP e.egn




 +2  upvote downvote
submitted by sahusema(117),
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esioacsdtA snplamose ni Fauimir-Len nyermsod. s,acrSamo baetrs cacner, inrba ,mutsor latrdeinacocro rmniacca,o amkieule




 +1  upvote downvote
submitted by mcl(501),
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Oehrt ayw to gte tsih tsqieuno is yb nntameilgii roeth isntoop -- isth freiug is ufesul ni gntilis smoe stnmiouta nad sactioadse nc.srcae




 +0  upvote downvote
submitted by kevin(3),

Li Fraumeni, Tp53 mutation. SBBLA cancers

  • sarcoma

  • brain

  • breast

  • lung

  • adrenal

kevin  leukemia not lung, sorry +