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NBME 21 Answers

nbme21/Block 4/Question#42

A 20-year-old primigravid woman at 12 weeks' ...


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The stem says that neither the woman nor her great-uncle had any other abnormalities, so they are examples of a "non-syndromic" cleft lip/palate, which accounts for 70% of all cleft lips/palates. It runs in families but has no distinct inheritance pattern and is considered multifactorial.

pg 607 FA -- Cleft lip & cleft palate have distinct, multifactorial etiologies, but often occur together