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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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meraHdyysaihotirppr nuigsca boen sseonli si aiv Ottasesobsl giasnernic KANR -L nprsoeeisx ot dibn to KARN on cssolteasOt nda situgmilnta ethm t-g--;& inc Bone nireRptoso

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pg32  iPkdce D edtspie esuanrndditng eht bveoa ^^ acuesbe IL1- is oasl knonw sa eststaoolc tivigcianta .t.foarc. +8
plzhelp123  ^ I did hte aems, ubt ti rpaspea atth I1L- actatives lstcoesstao ni etilumpl e.mmolya Wcihh kemas snees as taht is a onlspeam fo nemuim esllc iwchh nca ceodpur .nurilneitkes +
caitlyncloy  acn oannye eiaxnlp hyw tsih the aenswr is AA"REC"RPIN mo?ttilau?nis I elur uot the retccor nswaer ebcasue i asw uicipngrt KRNA nad RAKN L gi,nbndi hichw si otn anre!cipa?r +1
caitlyncloy  ..oh ti mese KNAR L si edcerets ot aacvttei teh l.s.tsac i saw tnriciupg ti as RKANL was on het rcfause of het stb.la fe ne:rrece .IAcaJy//ethh:btw.o/wsuuv?esRot=weBctOptwhm +1
makingstrides  If you ,anc I dlWuo hlyihg dormceemn ingoolk at the tshycek amprh for t.shi tI xsnaeipl stih well, ni ym ooin,pni dan dtnfeiieyl hlpede me. +
jatsyuk38  naljGo I vdolce'u rnosw adis HTP autlmstise oetssoalbts to esecter 1I-L to taiecvta ts.csatoosel eH oasl dias grneteso nvserept sioertoospso yb gitnhbinii beosltstoa saeelre fo 1-Iv.ewrL.eho. etehr is olas a dlUrWo uiqonest eherw ti sdia RNKL-A ylpas a erom tntpiroam eorl tcroa oer(v )1-LI in THP adeeimtd nobe kbdorwane +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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