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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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rsadpyhmpiatryeoriH cisganu ebno lensois is iva tOlbstoeass egicrnasni ANRK L- enxrepisso to dbin ot RAKN no estclsaoOst nad lsgtituiman temh &;-gt-- cin oBen riRntseopo

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pg32  cekiPd D sepited sudairngtnned hte vobae ^^ ecbuase IL1- is lsao wnkon sa slstoaotce inivctgaita .aotf..rc +8
plzhelp123  ^ I did the ase,m tbu it ppaesar ahtt -I1L iaavettcs ssaoctoltes ni emltiplu mym.elao hWhic eamks esnse sa thta is a eaplsnmo fo menuim elslc hiwhc can decopur setnlkni.euir +
caitlyncloy  nca anneoy pxilena yhw isht het rnaswe si E"RIRAPNCA" ?tunm?taloiis I reul tou het tcrroec searnw besucae i was igipuntrc ANKR nda NAKR L iignbdn, whhci is tno acep!ir?arn +1
caitlyncloy  .ho. it emes RAKN L is dcereest to atitaevc het .lstc.sa i aws gtniiupcr it sa RLKAN was on hte uescfra of the a.tlbs :cf reernee /tosa.B.yewv/tbpu=/:wshwheAmthctct?RIeJwuOo +1
makingstrides  fI uyo ,nca I odlWu ihghly eommcdner gioolnk ta the sekhtcy raphm ofr ht.is tI napilsex isth e,wll ni my inoniop, nad fyeditnlie pdehel em. +
jatsyuk38  jlaGno I c'ovedul rswon idsa TPH lutssemtia oseattlsbso to ceestre -L1I to itteacva ceslstostoa. He aosl dsai rnoteesg psrtneev siresostopoo yb iihgnbtnii stelboaots seaeelr fo hLw.ve-r.o.e1I rethe is slao a oUWrdl suetonqi ewreh ti iads KLR-AN lpasy a orem ptiaotrnm eolr toacr rvoe( )1L-I ni HTP eiedamtd nboe randbkowe +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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