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Retired NBME 21 Answers

nbme21/Block 4/Question#31 (reveal difficulty score)
A 48-year-old woman comes to the physician ...
Paracrine stimulation of osteoclasts by osteoblasts ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—tinydoc(276)
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hdyoerpryaipHrsmtai igcsnau onbe onilsse si iva oOstssatble iegsaincnr ARKN L- eiosenspxr ot ndib to KANR no osOattscesl dan laumtsitgin mteh t&-g--; inc onBe itopeoRsnr

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pg32  Pekcdi D sptieed nadinudgrtsne the obeav ^^ abeusce I-1L is also known sa sltecoatos vitntigaica ro.t..fac +8
plzhelp123  ^ I idd eht ae,ms but ti eprsaap taht -I1L avieatcts oetosltascs in pilletum lm.aoeym ciWhh esmak snsee as thta is a onleasmp fo nimume lcsle chhiw nca rpudeoc lusnreeitk.in +
caitlyncloy  can nnoyae xnelapi wyh iths hte aewnsr is NARA"I"PERC als?nitmti?uo I rlue out eth ccotrer aewsnr cbueesa i asw itipugncr NRKA nad ANRK L dninbg,i hhicw si ont nac?rripe!a +1
caitlyncloy  .ho. ti smee KRAN L si tceredes ot teactavi het lss.c.ta i aws upcirngit ti sa RANKL wsa on teh ecfruas of hte tla.sb ee c:fnerre /ytBt/pJeu/RcwItowAOh?cbh=:setutmvoe.wsh.wa +1
makingstrides  fI yuo na,c I uoWld hhlgyi ncremodem knoloig ta hte ceskthy hmpra for sth.i It lpxeinsa this lw,le ni ym onpin,io dan feitliedyn leedhp .em +
jatsyuk38  aonjGl I euldo'vc sonwr sdia HTP ttauselmsi tossboeatsl ot eecetrs IL-1 ot aeavittc tolstco.eass He olas idas tgsoreen tepevnrs oieosrootsps by iigtnbiinh batetsosol sarleee of hr.e-Iveo.L1.w ehetr is asol a odlWUr iousneqt eehwr it adsi A-RLKN layps a more aoimptntr loer aoctr ve(or LI1)- ni HPT aemddeit obne anrwoedbk +1

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts" Amboss

Not sure why D is wrong

+/- alexv0815(10)

Primary hyperparathyroidism: overproduction of PTH by parathyroid chief cells Effect of PTH on bone โ†’ increased bone resorption โ†’ โ†‘ release of calcium phosphate โ†’ โ†‘ calcium levels

Induces RANKL expression in osteoblasts โ†’ binding of RANKL to RANK on osteoclasts โ†’ activation of osteoclasts

Induces IL-1 expression in osteoblasts โ†’ activation of osteoclasts

Not sure why D is wrong

+6/- alexv0815(10)


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