hungryboxThis is wrong. PLASMA cells (mature B cells, the ones found in multiple myeloma) secrete antibodies, but IMMATURE B cells have antibodies that haven't switched classes yet (IgM and IgD).+22019-05-31T14:46:23Z
hungryboxTo clarify - immature B cells have antibodies attached to their membrane.+2019-05-31T14:46:56Z
seagullI should have clarified that I was speaking about mature B cells. Thank You+12019-06-08T15:22:10Z
sahusemaSo because MM has mature B cells, exogenous antibodies can't attach to them. Am I getting that right?+2019-07-18T17:26:41Z
cienfuegosWhat is an Anti-Idiotypic Antibody?
As shown in figure 1, an anti-idiotypic (Anti-ID) antibody binds to the idiotype of another antibody, usually an antibody drug. An idiotype can be defined as the specific combination of idiotopes present within an antibodies complement determining regions (CDRs). A single idiotope, is a specific region within an antibodies Fv region which binds to the paratope (antigenic epitope binding site) of a different antibody. Therefore, and idiotope can be considered almost synonymous with an antigenic determinant of an antibody.
cienfuegos@sahusema: almost exactly correct, but it's important to note they are talking about idiotypic antibodies specifically because by definition these bind the "idiotype" of another antibody (see definition above)+2019-07-23T01:54:54Z
seagullIdiotypic means --- antibody against antibody. B cells don't have surface antibodies but mere synthesize them. +12019-05-29T16:39:51Z