NBME 21 Area labeled ‘C’ (Caudate nucleus) (NBME Answers)

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Retired NBME 21 Answers

nbme21/Block 3/Question#23 (reveal difficulty score)
A 43-year-old woman dies after a 10-year ...
Area labeled ‘C’ (Caudate nucleus) 🔍 / 📺 / 🌳 / 📖
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submitted by ∗hungrybox(1277)

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Huntington's disease

anticipation: she has a similar disorder as her father but died earlier

Remember "HUNT 4 an animal, put it in a CAGe". Huntingtin gene found on Chromosome 4. CAG is the trinucleotide repeat:

Chorea, caudate nucleus
Ataxia
Gloomy (depression)

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sbryant6 Side note: atrophy of the caudate nucleus leads to a widened anterior horn of the lateral ventricle. I've seen it worded both ways in UWorld. +25

sbryant6 Side note: atrophy of the caudate nucleus leads to a widened anterior horn of the lateral ventricle. I've seen it worded both ways in UWorld. +

foulari112 How would you differentiate this from Frontotemporal lobe dementia +

temmy Foulari 112..the ageof the patient and the anticipation cos her dad had it too. Also in frontotemporal pick, you will see personality changes where they act completely different vs huntington where they are aggressive and depressed. +2

castlblack CAG = Caudate loses ACh and GABA (from FA) also points you to caudate +

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submitted by ∗kentuckyfan(47)

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A labeled image

A/B look like grey matter to me

C looks like caudate nucleus

D looks like anterior internal capsule

E looks like thalamus

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lilmonkey yep, I also chose C. Relatively easy question, but a bit misleading picture. +1

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