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NBME 21 Answers

nbme21/Block 3/Question#14

A 35-year-old man is brought to the emergency ...

Activation of adenylyl cyclase

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submitted by mcl(223),

Vibrio cholerae is a gram-negative, comma shaped bacteria that can cause watery diarrhea. Cholera toxin functions by activating the Gs proteins --> increasing activity of adenylyl cyclase --> increased cAMP --> increased Na+ and Cl- efflux --> diarrhea.