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NBME 21 Answers

nbme21/Block 2/Question#30

A 44-year-old man comes to the physician because of ...

Leukotriene C4: increased;
Arachidonic acid: increased;
Prostaglandin H2: decreased;
Prostaglandin E2: decreased


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submitted by mcl(220),

This is a pretty good figure showing the conversion of membrane phospholipids to arachidonic acid/leukotrienes etc.

Blockade of COX enzyme by ibuprofen results in decreased production of prostaglandins H2 and E2, while causing the precursors to "back up" (increased arachidonic acid). This, in turn, results in increased production of leukotrienes.