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Retired NBME 21 Answers

nbme21/Block 1/Question#18 (reveal difficulty score)
A 61-year-old woman is brought to the ...
Donepezil ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +10  upvote downvote
submitted by โˆ—ergogenic22(401)
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elderly lady with slow, progressive memory loss, normal physical exam, no signs of depression, this is most likely Alzheimer disease.

AChE inhibitors are used for treatment because Alzheimer's is associated with low ACh. Also used are NMDA receptor antagonist (memantine)

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 +5  upvote downvote
submitted by โˆ—divya(75)
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Currently Alzheimer's disease treatment includes -

1)Enhanced Ach transmission (Donepezil, Rivastigmine, Galantamine

2) Neuroprotection via antioxidants (Vitamin E)

3) NMDA receptor antagonism (Memantine)

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lovebug  19FA, 536pg +
an1  If both vitamin e and donepezil are treatments, why is donepezil preferred over vitamin e in this scenario? +1



 +4  upvote downvote
submitted by โˆ—step1soon(51)
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During the Mental Mini State Exam (MMSE), a health professional asks a patient a series of questions designed to test a range of everyday mental skills. The maximum MMSE score is 30 points.

-20 to 24 suggests mild dementia -13 to 20 suggests moderate dementia -less than 12 indicates severe dementia.

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