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NBME 19 Answers

nbme19/Block 1/Question#31 (6.1 difficulty score)
32 yo man given primaquine for malaria ...
Enzyme deficiency in the erythrocytesπŸ”

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submitted by cassdawg(959),

This is G6PD deficiency. (FA2020 p422)

G6PD deficiency causes a hemolytic anemia when individuals are exposed to antimalarials due to the increased oxidative stress. This is due to the deficiency in replenishing NADPH which is necessary to replinish reduced glutathione which aids in quenching free radicals.

cbay0509  thank you +