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NBME 18 Answers

nbme18/Block 1/Question#7 (reveal difficulty score)
33-year-old woman, mechanism of action of ...
Inhibits microtubule disassembly ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—okokok1(38)
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dont get tripped up on the wording. the answer is "inhibits microtubule disassembly". just remember, "taxes STABILIZE the economy" to remember the moa of paclitaxel and other taxanes.

the other answer choice of "prevents microtubule polymerization" is the MOA of vincristine and vinblastine.

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jbrito718  Vinca alkaloids bind and destroy tubulin in microtubules causing mitotic arrest VS taxanes stabilize the microtubules and decrease mitotic spindles. Both in M phase +
kcyanide101  I think of it such that Paclitaxel (taxanes)= taxes, everyone hates taxes...lol. and we are being taxed a lot so they are excessive. +



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