Activation of the mu-opioid receptor in the colon can slow gut motility. There are two opioid agonists that can treat diarrhea. The first, loperamide, does not cross the BBB and cannot lead to addiction or CNS adverse effects. The second, diphenoxylate, has some addictive potential by crossing the BBB (thus, you have to give atropine to prevent addiction).
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Activation of the mu-opioid receptor in the colon can slow gut motility. There are two opioid agonists that can treat diarrhea. The first, loperamide, does not cross the BBB and cannot lead to addiction or CNS adverse effects. The second, diphenoxylate, has some addictive potential by crossing the BBB (thus, you have to give atropine to prevent addiction).