jdc_mdInterferons: A part of innate host defense, interferons interfere with both RNA and DNA viruses. Cells infected with a virus synthesize these glycoproteins, which act on local cells, priming them
for viral defense by downregulating protein synthesis to resist potential viral replication and by upregulating MHC expression to facilitate recognition of infected cells. Also play a major role in activating antitumor immunity.+3
jdc_mdTNF-a also induces vascular leak and can cause the decrease in BP in septic shock +2
submitted by โandro(269)
***IL-1 , IL-6 , TNF -alpha can mediate fever and sepsis (These cytokines also known as endogenous pyrogens )
In addition to this : IL-1 - also known as osteoclast activating factor and activates endothelium to express adhesion molecules
TNF-alpha - causes cachexia in malignancy and maintains granulomas in TB