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submitted by hayayah(1212), visit this page
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Most problems with cell division occur in anaphase of Meiosis I.

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realfakedreams  @hayayah - made an account just to say thank you. I appreciate that you exist. +24
tekkenman101  Yup, Down syndrome? NDJ in Meiosis 1 in moms. Just memorize and move on. +
medicalmoraxella518  it's not down syndrome, Klinefelter Syndrome +


submitted by amirmullick3(76), visit this page
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The Lineweaver Burk Plot is mainly interpreted by its X and Y intercepts. The question states that giving B6 increases the activity to normal levels, which means the activity should be the same as the normal. Hence, their Y intercept should be the same, so we are between choices B and C. A and D do not have the same Y intercept as normal. Higher concentrations of B6 caused activity to become normal, and so Vmax will not be changing and we can cancel A and D. A has a lower Vmax and D has a much higher Vmax. The difference between B and C is in their Km. Moving to the left on the X axis makes the Km lower and tells you that affinity is higher so you would not need more B6. But in our case affinity of the enzyme for B6 is really low, which is why we need a ton more B6.

In summary, we want the same Vmax and a higher Km. We want the "normal" activity (same vmax as normal) and we need higher amounts of B6 for success so affinity of the enzyme for B6 is probably very low.

Choice B has a (-1/Km) value closer to 0 which means Km is lower and affinity of the enzyme for its substrate is super low. This makes sense as giving higher amounts of the "competitive" substrate B6 is helping.

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apurva  This explanation is wrong!!! X axis is not 1/km in the question, it is 1/pyridoxal phosphate. (1/km should be 1/homocysteine) Also the question is asking about allosteric activation of cystathione synthase due to addition of pyridoxal phosphate. Which means the Km should decrease (affinity increases after addition of pyridoxine). Considering the x axis to be 1/pyridoxal phosphate, now apply simple logic of maths, increase pyridoxal phosphate = bringing line more close to zero (because it is -1/pyridoxal phosphate). +13
apurva  Had the X axis be 1/km, the answer should be C +1
pinkdinosaur  Km is inversely related to the affinity of the enzyme for its substrate. The closer to 0 on the X-axis, the higher the Km. FA 2020 pg 230 +


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