NBME Answers : aturner713's page

Subcomments ...

submitted by enbeemee(12), visit this page

get full access to all content ⋅ become a member

i get why it's flagellin, but is the specific reason that LPS is wrong is because it's just not how the vaccine is made? LPS would also elicit an immune reaction, right?

get full access to all content ⋅ become a member

nor16 Lipid A of LPS can be sensed by CD14 of macrophages causing shock, its not a protein, so no immune reaction as in vaccination (humoral, IgG class switch via Th2 and B Cells). +4

eclipse actually they do use LPS as adjuvant in vaccines +3

hyperfukus TLRs recognize common motifs called pathogen-associated molecular pattern (PAMP) in bacteria, fungi, viruses, and other pathogens. TLR signaling in the modulation of innate immunity + adaptive immunity against pathogens, TLR agonists: CpG-DNA, flagellin, and lipid became essential candidates of effective+safe vaccine adjuvants. TLR agonists improve the efficacy of vaccine, reducing TCR-based selection thresholds and enhancing the magnitude and quality of memory T-cell response. +5

hyperfukus some extra info in case they ask another annoying q +5

aturner713 Not sure if this matters for this or not, but Neisseria spp. have lipoOLIGOsaccharide (LOS) and not lipoPOLYsaccharide (LPS) +5

schep I don't understand why LPS couldn't be the answer also. UWorld question ID 45 specifically says that they are using LPS as a conjugate +1

jp1003 I think it's because Neisseria does have LPS. They have LOS instead. +2

jp1003 *does not have LPS +2

thrawn Doesnt matter - we dont necessarily inject the same specie LOS/LPS in a vaccine - anything to make the immune system wake up to a threat +1

an1 The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides. But injecting LPS will induce shock and the 'ENDOTOXIN" cascade mentioned in FA +1