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NBME 22 Answers

nbme22/Block 4/Question#15 (reveal difficulty score)
A 24-year-old woman, gravida 1, para 1, comes ...
Release of stored thyroid hormone from a thyroid gland infiltrated by lymphocytes 🔍 / 📺 / 🌳 / 📖
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 +36  upvote downvote
submitted by liverdietrying(111)
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hsTi neo saw a ltteli rktic.y roF hist eon hte yek si hte low didrnooeiia .akpteu Thsi iatnpte hsa ihhg T4 and wlo HST cwhhi aemsk esnes ni a ydhpieyhrtro nai,ettp psapher ryou tifsr htougth is htta htsi itanetp ash evsar’G sesad.ei ewe,Hvro ni vars’eG yuro rodtyih is gbine emiulatdts to mkea eomr rotdyih hoermno ofrm hatrccs adn as uchs wdulo vhea an edirecans iiinaoordde ptkuea aecebsu hte hytidro is gnnirbgi in eth rredique now( diale)leardob d.noiei Thsi is hyw ti si nto sGaevr e(es“rlae of iothdry hoornme mofr a iorydth uaetdimtls by da”oen)iit.bs

oS fi sit ont Gsr’eav awth lodcu it be? roF ihts u’ody vaeh to okwn htta soih’maostH triiodsTyih a(slo nwokn sa corCihn otchyicLpym ryhiTdioist and si fnteo efdeerrr to as husc on draob exmsa to owhtr ouy of)f ahs eethr aesphs - siftr they aer yrr,tphieodyh hnet tiuehry,do thne hte cacisls dyyiohhotpr taht uyo oluwd pctxee htiw low 4T dan ighh .SHT ihTs was teh eyk to htis usit.enoq Teh aernso ofr shit si ahtt oinhrtaytid xieepodsra teonisibad in thss’oomaiH cueas teh tyodrhi ot eesrlea lla fo tsi seotrd htdyrio hrmoeno nkmgia the itpaetn yieorhptydhr rof a hrsto oepdri fo time. fteAr shti ivamsse esaerle fo rdiotyh nohmeo,r het debntsiaoi ekam them baleun ot amke nwe TH nda eofhretre they ceoemb tyherudio rfo a trhso poiedr nad hetn ootripdyhhy ihcwh oyu owudl eetpxc! inecS yteh ’tcna ekma enw ,TH the yhdrito lilw not ekta pu eth randdiooeii nad oreetrefh heret will eb owl aieoriodnid uek.tpa nc,Hee e“rseale fo etrdos iyothrd neorhmo rfom a ihodytr dagln aintftdreil by eylts”pc.homy aka coymLhtic“yp tohhsa(som)i dytiho”siit.r

I inhtk raeels“e of oidryht omroneh ofrm a mypoulsamoht iydhotr ”dangl si frirgrnee to meos nkid fo toyirhd erncca in chwhi seca ouy oudlw ecpxet mhte ot be gcisdrebin a odnelu no arieidonoid k.upeat

​muSarym oediv reeh and losa a great etsi in angr:lee rarpdenotiiem.ilg:ant/o//rneyctspuorieheqdcs//dne/odh

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aesalmon  gp 338 of FA itsls ti duern itrpidosomyyhh tbu ti deos rtenpes sa ntsaitern spoeiyrityhrhdm sirtf +9
hyperfukus  epy hatt was het !eky reiotG si ""OHT utb eth nrmigeina sanwer sohccei erwe tlsli ndik of ebhl D aws idatrigtcsn eth lehl tou of em i nptse so ognl to ocnveicn lfemys ot pcik C dan ovme no +3
hello  tiPagsn ennmn'akwnisl emtmnoc as an :aditdnoi oCeihc "D" si norgw b/c has"mymtloupo rohidty "dalng = impryra dhoyirt hlypammo lc(tpiayly ,HLN ihhwc is veyr arre) or oimhsH'atso rohytid soprr.onegis som'hoitasH drtshyiioit = oilchpycytm rfttienlai hwit lngamrei B lscle and hurtHle lscel, hhwci uonp ecinnuotd ois,tlutimna can edla ot tam/aiontltnnamiug ooinrmttnfasra ot B llce lohpmaym. htBo of steeh nerespt tiwh hrosthyipyimod htiw owl T4 and hhig HTS oopp(seit fo stih enapit)t. +1
taediggity  I ltsaulobye voel oury rytdnev,geii@ilr hvoerew hte seensgoapith fo osptumaptr sytoiitdrih is laimrsi to o,osismtHah' os I kthni htis psnero sah pstrmoptau soiyhridtti and yrou laoaintxpen of netstniar iooxoithysstcr si tspo on, hhcwi ouwdl laos ccoru in orpumatpts irstihdityo +16
pg32  I agere wthi g@ey.gititda oAsl enot ahtt oemwn evllenayut orrcvee omrf stpaproumt idihotstyir and lyaltycpi boemec tiryodeuh aniag, chwhi den'sto appnhe wtih ioHsms'.toha +
vulcania  In FA 0(921 .p )833 ti sasy tath hiydtro is lulysua mronal zies ni parstmupot dhtiiiro,tsy utb eht ipatent in shti qseuoitn had a riytdho wt"cei het mnrola "zsie. I gessu ta teh ned fo het ady ti todesn' mertta wichh gisisdnao si girth rof hsti qetsioun ucaes hety othb emes to aedl ot teh eams etccrro wrsnea ): +2

This is definitely not Reidel's thyroiditis. I remember getting a question wrong on UW, in regard to subacute granulomatous de quervain's thyroiditis. The pathogenesis is granulomatous inflammation destroying the thyroid follicles and releasing stored T4/T3, with a LOW radioiodine uptake. I think this line is super important to get the diagnosis right. Like liverdietrying mentioned, you need to understand that in thyroiditis of basically any cause (postpartum, hashimotos, subacute), there is a release of thyroid hormones leading to a transient hyperthyroid state which then BECOMES hypothyroid later after a brief euthyroid phase. Hence the term thyroiditis, inflammation of the thyroid gland, with release of it's contents.

+/- imgdoc(183)


 +23  upvote downvote
submitted by hayayah(1212)
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siTh is a ietatnp scea fo aopmsptrut dytihis.roti nCa aersi pu ot a ryea eratf eldiyerv nda has oytmiplychc tea.ftrlnii

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almondbreeze  FA 1092 pg 383 +1
waterloo  lghhtoAu isyhort smsee to otipn sarowtd ,ttha esh hsa an elaengrd tdoyrh,i adn ni mtsopraput sirhtdii,tyo thydoir lslayuu mlrona ni iezs fom(r F)A. rgalsrseed irhete loduw vaeh eoysctmyplh iftningitral. +



 +4  upvote downvote
submitted by nwinkelmann(366)
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hTe aonapnlxtei by ryilgviidetren spul eht alaetxnipon in the irtaecl stdoep bwole (ip.M96lns/ctcsho/wn4b.mnem/r9/tc/t.wCgvip9wP/.ila4:h8) are the est,b stuj deen ot eb dbcenoim :.) eTh afrliiefdnte aosdngsii laetb 1 (0nwBi4ii/-Pwyea9ems.rtt0vcb.lcl/1gmOL4.r/-onSctoj.11Cw9=cer8//9?6:p/onteo/Mn4/tThpabplMlst-b0h) ceylcilafsip sntdieiief the nioinoctd ni isth enosqtiu sa asppotmrut ohirtii.sydt

myal,teiUlt if oyu okwn htta tmyrihydsihoop sha a snrtiatne rhdorytisipyhem ahpes u(ed to euommuiatn ictunrtdseo fo eht lcesl ichhw ledyaar hda frdmoeerp HT nad os ti swa sdealree opnu c)turestnido eeobrf ihrsomthydpioy n(ninoitfnconug lcels so 'tcna akte pu ndio)ei dan hatt dirtoyhophmysi is a lctycmohpiy lgttriininfa tiioyhi,trsd ouy wlil onkw eth nsew.ra I adh a rahd item snnrteaugnidd this ta sifrt uaebecs ew euoltvie/saeangda desab on hte eprcense of in-TatPO ,Ab tub teh nidnguylre ehspitaeosng of the tihrdoy riutencsodt si acidtleedlme- e(tpy VI vyni)ihytipstrese ont Ab ieaetmdd p(yet II esrttpsniiyv)heyi leik egvs.ra Hthoissmao' = thpmoyclicy rnlfiitainot ihtw iengamrl setncre hc(iwh can atomsrnrf ot B cell m)ympohla twhi tehhlru elcsl n(rekip pyatlmcso llec)s.

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 +1  upvote downvote
submitted by niboonsh(409)
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aCn soeenmo lenaxpi the nefcefierd etweenb .C arlsee(e fo drtoes rtioyhd ooehmrn frmo a dtyriho ndgal lfrdineatit by ytemcpsl)oyh adn .D sl(eReea of yirhdto oermnho rmof a mooyhpmtlasu iohyrdt adnl.g

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drdoom  ,onsnihb@o nindeg a mmtoenc hitw a seoqutni mrak lliw mkae ti rppeaa no het moentcsm" ienskge erassnw" stsli +4
nwinkelmann  A ymmahsuploot dhtrioy gldan cna trheie eb ued to yrarmip dtyihor mpmoalhy i(hhwc is amoslt syaalw LNH, utb is yerv )rrea ro ued to msshia'otHo otrihyd noes.grroips somt'hHaios ioiyidtrhts = plyoicymtch eainrlftti twhi rilmnega B sclel dan trlhHue lsc,le ihwhc npuo ncndioetu nmu,tslaoiti can aeld ot ttn/malitannoaigmu oafotatrmnnisr ot B llce olpyamhm. e,Tesh I beli,eve wlduo lltis enerspt tiwh ihtpsy,yiohrdom dan uhts uodwl vaeh lwo 4T adn ighh HST ies(tppoo of sith tetinap). +1



 +0  upvote downvote
submitted by seagull(1933)
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ws9nsr4oci6.9w./nb/h.t.4P8lhinmaitve9//pwt:M/cClmg/pc

odicgAncr to tihs papre, ttomrPpsua iiodyThrits ntsrpsee ihwt -PTianOt adsboeniti. heT swarne oheicc ssue yl.eshotpycm oS htis is a ratietsnn hsotmoaHsi mirsoetHh.riypyd dGoo ckuL hiwt atth o!ne

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seagull  DITE: chLptyeysmo era laso ptenesr in iths sa l.elw My adb +1



 +0  upvote downvote
submitted by hyperfukus(111)
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I inthk htta sicne eryh'te isgakn ofr an netnloapxai of hte i'tpensat rretcun xSS hwihc shsow htat s'hse in eht tetas of isTnrntae yHtershpyi:oidmr hhicw is due ot :C eaResle of dsetro oidtrhy omrneoh omfr a rdiytoh ngdla ianltdteirf by yomhtpeycls

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 -1  upvote downvote
submitted by mdmikek89(6)
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uubceSat ymlhyoctcip teySdiiahursc otiubt tpcymyoilhc ttdiiysroih si aczcdehrtriea yb damgea ot uairlcollf clels tiwh cylpyhictmo ltitnonfiria snelrgeimb toissaohHm' hsdiiioytrt sadtnie of uoaamgrln iomonratf. sDu :rg ro,-αfeietnnr itiu,mlh mrai,ndaoeo -ekl2,eniunrit sonetiry aseikn Anumutr ihioebmoistni dseaesi a rspuotmPt otsityirhi:d ctefsaf %5 fo nwoem dirugn teh tpopumastr eproid dan is 3 isetm omer cnmmoo nmago mweon hitw tpye 1 eaestbid mlseiu.tl

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