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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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iDd yeanno eend to edar ttha stal ceetsnne keil 50 mstei sebauce het hrouat reefssu ot seu breett r.agmram utJs at.riftsngru

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link981  tAruho rnaeta:loi a"Wth is a"gra?rmm +6
qfever  Ddi annoye edra eikl 50 sietm dna still gte it wgr?no (OL,L e)m +22
drbravojose  Aatlculy nreev ndreudtnsa ahwt the hotura asinyg at ayn it.em OLL +3
alimd  Suhc a shtyit u.qnestio Do ew rylael veah cshu qnseustoi no teh arle xeam? nI ym inoipon eyth tsuj rhotw nujk iqesotnu to estho essassnmte +1
nootnootpenguinn  hO ym osden-sgo khnat o!yu I saw os dam at hoveewr ewtor hits istyth nsiuq!eto G(to it wgron ll)o +
xmen  HYET IGEV TIOESEMM WEIDR QONTSIUSE NDIGUR EHT ALRE EXAM !NA! D! I'ST LPNTEAEMERXI +



 +12  upvote downvote
submitted by ∗hello(429)
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eTh armgrma fo hte ucalat Q wsa conngfusi.

To keam tterbe e,snse it lodush ays hhWc"i of het nlolowifg is teh smto eiylkl ertusl no eht oittrnsrniacp fo eensg ttha tibniih ellc oiviisdn dan ahtt ninotac eht soeuscnns eesquenec A.T.T.A"

So, hte Q is skigna bouta eht 53tp eegn nda sliaelycfipc atubo eht 5tp3 ngee morotpre ngeiro.

omPorert ngrioes have a TATA xob oi(svylob,u aginnme hcri in -TA bsae spir.)a T-A abse ipranig sha 2 edoghrny db,son hwich aemsk hemt areise to clvaee -tg;-& wallso ofr DAN rpnrctisiaton ot courc emro sleyai. RNA olP dose sirnnrictatpo fo ADN oitn NAR.

eTh riente tes-Qm atlsk buoat who aLeinrFimu- is ude to a ontutami ni t3p5 ee,ng dinagle to a cakl of tormu nussoeppirs tcyait.vi

,So if eth rmpoteor egniro AATT obx fo teh t5p3 nege si eatudmt, tneh the 3tp5 egen wlil not egt aestdrincbr ;&--gt sith si why etreh ilwl be eedscaerd NAR Plo n.ibdign ARN olP will ehva a deruecd lyibita ot nibd pt35 -;g-t& lses oturm resurossp eegn pttnnricrosai g--;&t ssel orutm pines.usrosp

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jcmed  that uwold be yolrve seay of emht hthoug eye rlol +
whk123  eBst oinxaan.tpel +
fhegedus  adn yseudnld vrhtnieyeg amkse essen D: aknTh yuo orf a ratge pxnaaoietnl! ): +



 +8  upvote downvote
submitted by ∗fenestrated(32)
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orF htis neo I nhtik whta uoy adh to kown is htat sairTntncriop NA-tA-&(g)RN;D is rfedpeorm by RAN y emltIpaers.o saw tno DAN lespoemyra aebecus shit oen esricatelp )NAAg;(t--DD&N

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fenestrated  bweente edascrnie or rdeaecdes nbngdii I ikpedc dsaedeecr buacees it aws a anttuiom ihhcw aeftedcf teh eghdrony odsbn chihw si owh ldnctisueeo nbdi to ehac toreh +1
makinallkindzofgainz  thsi si woh I otg ti grthi +



 +4  upvote downvote
submitted by ∗yotsubato(1208)
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3p5 si datetum nad tcan bdin the TAAT x,ob so ahwt psnapeh ot rntornitpicsa of tiiiboyhnr rpneo?sit

Is lsbcaylia athw iths isenqtou is ryngti ot as..k.

oS on TATA box rreoptmo g=;t& dascDeeer ingndbi of ARN opemlaryes

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link981  uoY dais ti, ethy era ing"tr"y ot ak.s hloSud use retebt argmrma. +3
titanesxvi  sThi si on tisrf d,ai nda syas htat teh rmooretp ogeirn is rweeh eRaeyrNlpsmAo indbs +1
nootnootpenguinn  aauHnk NT-OTAA .b..xo nkhta oyu rof isht apaixen!lton +



 +3  upvote downvote
submitted by ∗d_holles(218)
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sihT is a godo pcetuir of an metnepixre swgihon :tsih

2ic2rw/au/thi:ges1.1ot/ptrst/n0f/6.l1aeeswc9/umrw

enceogOn vomuel 62, aepsg 22922–112 0)07(2

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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Wyh is hist nto dreniaecs ginndib fo ADN el?eoapmsry

Tshi itonautm dosulh asceu llacruel iiviodns ei DNA tcleonriipa dna asuce aendrecis nidbgin ot ongiri cpaniietlro eusesqcne ei TATA yb NAD lropyesma.e

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brise  I'st gatklni toaub tnsotimau on eth nspotarnciitr fo negse ttha inbhiti the clle viidnosi. oslA ANR mepaysrloe sinbd to hte rmoporet ire.gon +
nwinkelmann  olA,s teh sunteiqo cliyisfapecl ghho(ut ni a reyv dyowr, vloeuocntd w)ya akdes whta het fcetef fo eht tioaunmt no tiintsnorcpra .swa DNA plo si ont sued in rnnctsor,iatip it is udes in .iiparcnteol RAN opl si ueds ni rrposi.anttcni nI rstme of neiscared or eadcseder gibn,ndi inngraig is posa/ipvitlyelro chgdaer and plnorei si nlarrtnleu,apo/no so reteh aer efrew dgnobnH-i ise,st dan tush daesedrce dgiibnn of teh NAR o.pl +1
medn00b  dClou ihst toecdulnov qnesiuto aosl ..t.hemat....a .n.. nicse eth gene to akme 5p3 is mdesse up deu ot eth hryoendg nodb,s NAR moayeslerp lilw ton be blea to ibdn to kmae the mARN ... So erthe iwll eb cc?anre ecaesBu 3P5 si a umtor sppre.sruso.. mleem kown ahstnk syug +



 +3  upvote downvote
submitted by ∗jessikasanz(9)
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otl of dowr oivmt to ksa wtha" snbid to hte AATT "xob

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 +0  upvote downvote
submitted by pipter(10)
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seoD yenona eahv nay pisifecc daie no teh chaesmnmi fo teh 53p nttoumai oeuqitsn nrdgirgae the TTAA obx h(et eno iwth the gnslei mnoai iacd noivcoersn dan het rnfdetief dyrnogeh ngib?)don

I ehosc the ceddsreea nidgibn fo NAR mepeyrlosa on eth ATAT ceequsen of gnees atht nitibhi clle ionisidv eadsb ysolle no eth cfta htta 35p si a rtumo usresprosp aa(k uatedtm gts3l;s5e&-p niiihboitn fo u;&ioviidm-elptgsnlti s.ii)doivns

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joha961  oFrm a amonrd appre I fdno,u glA“rauyb 35p’s ostm rnopmtita cotnnufi is to cat sa a istintacrponr fcroat tath leyidcrt rulestega prespah velsare urnhdde fo hte scle’l RNA oyleemspar II APN(R -cIir)atnbsdreI ”eegsn. So oylalmnr it isrencsea NAR pol ;innibgd a umonitat wdlou erdcsaee it. +1
estsosa  Teh TATA bxo si prat of eht rooepmrt gniore tesi heerw ARN eyrampseol II adn threo inrsitcpantor tafocsr bidn to AND. A dcfete lwodu teerohfer eaeerscd gininbd fo NRA smeyreaplo. +7
mnemonia  oAsl uyo cna eosrna ti uot (I gto sthi worng abesuce oyu haev ot eb yealrl ceulitms)uo esnic we wokn thta olss fo p53 = e.ancrc cenraC = ntaw omer llec nosvidii = dton’ twan yihinbtroi egen = sles atrsornncptii fo dasi .geen +1



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