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NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by seagull(1933)
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Did yaoenn eend ot adre atth last tsecenen lkei 05 iemts eesbuac teh uahotr rsseuef to eus ertbte amr.garm sJut autirtsfn.gr

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link981  Auhrto :toilaenra "hWat si mrrama?g" +6
qfever  dDi enanyo raed ikel 05 etism nda sllit egt ti gow?nr (LOL, e)m +22
drbravojose  uaclAtyl nveer rsentdudna ahtw het ahtuor gsinay at ayn ietm. LLO +3
alimd  uhcS a itshty ine.suoqt Do we arylle heav hcsu noqusiets no the aerl me?xa nI my pnnoioi ehty jtsu trwoh kjun qunseoit to shoet seasnsesmt +1
nootnootpenguinn  Oh my -eogdsosn nhatk oy!u I asw so dam at vwerohe erotw hsit hsttyi qoeinsut! to(G it nwgro ll)o +
xmen  EHTY VGIE OIMEMEST DWIRE QTSSEIONU GURIND HET RALE EAMX !A!!ND SI'T XMIRTPNLEEEA +



 +12  upvote downvote
submitted by hello(429)
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ehT amagrrm fo het tcalua Q asw gnonc.fsiu

To kmae tetebr ,nsese it hdlous sya hWhc"i fo teh ofnilwgol is hte tsmo ikelyl eutsrl on hte tonricprantis of seegn htta itnibhi clle iviodsni nda htta toicann eht soesscnnu esecueeqn A".T.A.T

S,o het Q is gksnia batou the 35tp ngee and lsflcypicaei uaotb teh t3p5 geen rrmootep gnorie.

romotreP oeirsng aveh a TATA xob ly(,suiovbo gamnnei hirc in -TA seba )ap.ris T-A bsae npragii ahs 2 odeyghnr onbd,s hihwc esmka them areise ot celeva --gt;& laswol for NAD nnaptritcsiro ot cruoc mroe eaysi.l ARN lPo eods rtipnoticsnar of AND otni NA.R

hTe nreiet -mQets sltka batou owh -irmuaLFnei is deu ot a timntoua in 3pt5 ,egen giednla ot a lcka fo tmoru sierpsuspno itit.cvya

,oS fi the torermop ogrien ATTA box of the p35t nege is um,tadte hnet hte t3p5 neeg iwll nto etg creansbirdt g-&t;- htis si wyh herte llwi eb ddsrecaee ARN lPo .ngdinbi NAR olP ilwl hvae a erdecdu btliayi to ibnd 3p5t -;-g&t ssle rtoum serruossp gnee ricrnstatonpi -;>- sels orutm ussprsi.noep

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jcmed  atht uwold be olrvye saey fo ethm hugoht eey rlol +
whk123  eBts xaioaletp.nn +
fhegedus  adn nedudysl hentriygev ksame esesn D: Takhn uoy ofr a taegr netxoa!ipanl :) +



 +8  upvote downvote
submitted by fenestrated(32)
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orF hist noe I tinkh atwh uoy hda to konw is hatt aoTsrnitripcn gA-At&()NDN;-R si repedormf by RAN latprs y.emIoe aws otn ADN yorpmaeels ebuseac shit eon tlierasepc NAA(--ND)D&t;g

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fenestrated  bnteewe asiecdren or cedeaserd niidnbg I ciekpd radsecdee aebseuc ti saw a ttmaouin hwich cftdefae eth hnydroge ondsb whihc si owh ncoudesilet bnid to hcea hoetr +1
makinallkindzofgainz  hist si how I got it gtirh +



 +4  upvote downvote
submitted by yotsubato(1208)
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3p5 si dtmtuae dan ctan nidb het TAAT bx,o so awht enphaps ot iorcttnniarsp fo tiyohnirbi ?oisretpn

Is lsciabayl twah hsti esounitq is giyrtn ot aks...

oS no TTAA bxo opeotmrr &g;t= deaceesrD ibndgin fo ARN psreoamley

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link981  uoY aids t,i yeth rae gr"i"tyn ot .kas ohSldu seu etterb amarr.mg +3
titanesxvi  shiT is on risft ,adi adn ssya ttah teh roetormp noiger is herew oyAelNmreaRsp isdnb +1
nootnootpenguinn  Haunka TATNO-A xbo... haknt yuo ofr hsti ptaanln!oeix +



 +3  upvote downvote
submitted by d_holles(218)
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sTih is a dogo cuptrie of an npemertixe wsgoinh sih:t

p:r//hue06i21tttwuna./tci/1lo./mgres92rw1ecs/aswf

enngeOco meuvlo ,62 spaeg 22–211229 0(702)

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hWy si stih otn eidrscane nbiding of NAD mseepy?lroa

hTis totuaimn lousdh cuase calulrel dvioniis ei NAD iceploitnra nad eacsu acdesiern ignbdni ot iionrg icoartplien eesnueqcs ei AATT by DNA lopasey.erm

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brise  stI' tiagkln btoau onmutasit no eth iprntsnatocri fo esegn ttah hnitibi het llce dns.ivioi Asol RAN smrepaeoly bsidn to eht retrmpoo rg.enoi +
nwinkelmann  o,sAl the eqnostui yfplslicaeic (hhougt in a yerv dryow, vectundolo a)yw kdase ahwt hte effect fo eth totuianm on rttnaipioncsr s.aw NDA lpo si otn seud in staircnnrpt,oi it si edsu in rnc.atleipoi ARN plo is esdu ni sanrtipnot.irc nI rmtes fo acsdiener or decedsaer ,inidnbg gingainr is litsov/lroppyaei gdharce dna roienpl is anouprlrln/netao, so ether ear feewr -odnnibHg s,ties nad tsuh scdeeaerd inndgib of eht NRA po.l +1
medn00b  Cduol thsi ldotuvocne ntsiequo also .nth...ta ...m..ea. ceins eth neeg ot kema 53p is messde up eud to het ghrodnye osd,bn NAR oearlspemy iwll otn be laeb ot dbin ot eakm teh RmAN ... oS reeth ilwl eb nc?arce ceusaBe 53P si a ruotm rs.surppe.s.o emlem nkow ahkstn ugys +



 +3  upvote downvote
submitted by jessikasanz(9)
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lto fo wdor tiomv to ask tw"ah bisnd to hte TATA box"

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 +0  upvote downvote
submitted by pipter(10)
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oDes aeynon veha any pfiecsci eida no hte cshmeainm fo eth 3p5 timnatou ietqosnu reggrdian the TAAT xob (hte neo wtih hte senigl aionm icad noericnvso dna hte nfretifed ogydhrne )nnbd?gio

I ohces hte ersadcdee inbdgin of NRA slreeoyamp no eth TATA eqencues of egens atth ithnbii lecl ovnidsii easdb osllye on hte atcf tath 35p si a romut ssspupoerr (aak mutetad p3l;5s&g-tes iniiobtnhi of ivm-op;igeutln&sdtili isnidsoi)v.

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joha961  Form a nmdrao peapr I uo,fnd lrayg“uAb s3’p5 most aiptnrotm ntonicfu si ot cat as a nicnrpoaisttr acrfot tath clerdtiy rlesegaut aehsrpp revlaes redduhn of hte lce’ls RNA peorlmyeas II (PRNA n)IrbaeIc-dtsir .snege” So lyolnarm ti esinscaer ANR opl inigbdn; a tnotiuam owdul ereecdsa i.t +1
estsosa  heT ATAT xbo is rapt fo eht merortpo goiner ites hweer NAR emrpoelasy II dna teorh otirrintsacnp acsorft ibdn to NA.D A fdetec dulow reroehtef eacdeser ingibdn of NRA eo.lmersayp +7
mnemonia  oAls ouy anc srnaeo it tou I( gto isht wrgno cuabese yuo evha ot eb erllay cteiuolm)su cenis ew wkon atth ossl of 5p3 = acr.enc rCcaen = wtna oemr lecl odinvisi = ’tond twan tyhriinobi eeng = elss ncirttspniroa fo idas eegn. +1



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