dneaiMlan in:teescG
nMa sha 32/ anchce of ngbie a rrrac.ei (He esod ton ahve hte e)sedi.as Wmn ao craerir sikr smut eb educcltlaa iwth p2^ + qp2 + .2^q q2^ = 01,/0040 q = 2/0,01 p si rhyguol = 12 qp = 001/1 = raierrC qneeycfur .
ksRi fo anivgh a ilcdh suth squlae 32/ x 0/101 x 1/4 = 1/060e/u2 ce3sB:a = naM reaCirr rkis 01/10 = aeeFlm rearrCi ks4/ Ri1 = enCahc tyhe eahc sspa no the seeeircsv gene to irthe rnsfif.pog
siTh hte aems sa @ysnkcepym'oa aapitxnolen thwi orem ipennoaltxa hetos tath ened .ti..
hTe tnepait si fetducaefn by hte aarlipucrt tmlaaouso eecersisv saeside dna ihs bhoerrt hsa eht utoalmaos isveecsre diasees ;t--g& hits nmase ahce of rheit rnateps aecrrsi teh AR lelela. ,oNw rof eht aenttip ot be cnaudfeetf ngevi ttha obht hsi stnaepr ehva eth AR laele,l ti maesn ttha eth tpaetin sah a /23 hncaec hatt eh si aulstmnoieulsy aufeedcfnt adn a ae.ircrr
Teh nstapti'e traernp is ueafdcftne nad lrmoan eWid-bryrangHe tcingese sa( ttseda in teh m)nlo.webpr.he ihst is aielsclcpyif enmo,dnite you aer to emssua tath hte reaptnr has a ecarrir feqycnuer fro eth RA elel,al whihc aqeul to pq.2
hTe idasese sah a cnrefueyq ni eth tpuooaipnl fo .10400/0 isTh is ^2q t;&-g- ^2q = .401/000 gvSoiln ofr ,q you tge q = /.2100
erarCir ynuefceqr si 2q.p ervwHoe, rof a arre ,aeidess p2q ≈ 2.q ,So teh erarcri fyeecqrun orf teh pertran = q2 = 2 * 210/0 = /001.1
Nw,o the Q assk uobta an gsffniopr of het ntitape nda sih anprter ingeb ffaeedtc, os to ehva na efctfaed hil,cd rehet si a /41 aencch fo hainvg an ftfaedec lchdi ss(bcueea eht ettpain and hte nratrpe btho evha a 12/ hecnca fo insapsg teh leaell --tg;& oyu mlepulit eseth roegtteh /21 * /21.)
,So ultlyipm 3/2 * 1/001 * 14/ = 60.10/ hsiT si etiPn(tap inbeg a eira)crr * (Pnrreapt genbi a rarrice) * Paghivn( na tffeacde gofrspnif tehet)rgo.
eTh aloitbbripy fo the tfearh negbi a rcrarei is /32 cnise ti si nwkon taht he dotens’ vaeh eht .esedais Tnhe hte tyirbailbop of mhi ipsagns it on to ihs dik i:s
21/ * /23 = 31/
Whit hte dbn-eeiWayHrrg ,plnericiP uoy anc erufig tuo eht lbtaoriypbi fo het tormhe eignb a r:ciarer
q = )t00/(1rq4s,00 = 0/210
,So pq2 = 2 * 0/201 * 9/20910, whhci arxopp is 01/0,1 adn eth tiaiobplyrb fo het lcdhi gietgtn hist llaeel is 001/1 * /12 = 0102/
Tu:hs
01/20 * 1/3 = 06/01
wyh theer is birytblapio of atehfr neibg a rrcraei is /23
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFlcoustinaaCl rof add. hTe pyiatiolrbb fo eth erahft neigb a ierrcra si /23 ncsei it si nnkow ttha he dn’sote heva hte s.eidsea Tneh eht apirbibtlyo fo ihm ngissap it on to his ikd si ,21/ s:hut
tsuonaicllaC for omm. tWih eht iybee-rargHWnd re,nipPlci yuo nca fugeri uto the bitoibylpra fo het rothem nigbe a irecra:r
q = s(0r/q04,)t010 = 210/0oS,
p2q = 2 * /0201 * /120909, wchhi is oxarpp 1.010/roF eht dhilc ot get eht llelae orfm mm,o wto gsnthi eden to hpnaep: )1( mom mtsu be a rraeric ]oeygteoer”[zht“ dan (2) mom utsm spsa teh laelel to hli:dc
gutiPn it lla hgeroett. woN, ionmecb lla reegtt:oh
= bypoiirab(lt of add eibgn ec)iarrr * oibtpar(ybli fo dad ignassp on daesesi lelela) * (airlbpbtoyi of mmo biegn earci)rr * tb(yrbaoilpi of mmo gsapnsi no isdsaee llee)al
=
23/ * /21 * 011/0 * /12=
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