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submitted by โˆ—step_prep5(246)
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  • Elderly patient with gram-negative bacteremia receiving gentamicin (aminoglycosides associated with acute tubular necrosis) who has developed oliguria and an AKI, most consistent with acute tubular necrosis
  • Acute tubular necrosis leads to pigmented granular casts
  • Causes of acute tubular necrosis: Sepsis, Aminoglycosides, ischemia/hypotension (spectrum of disease of pre-renal AKI), heavy metals, radiocontrast, ethylene glycol, rhabdomyolysis

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azibird  Yes. But I'm suprised no one has mentioned this yet, because it makes the diagnosis a lot more certain: Cephalosporins increase nephrotoxicity of aminoglycosides - FA 2020 +1



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submitted by โˆ—seagull(1933)
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Acute Tubular Necrosis due to Aminoglycoside toxicity (Gentamicin).

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submitted by dreamyyn(10)
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in addition to the nephrotoxic medication, the DIC can lead to thrombosis and renal ischemia -> another cause of ATN

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submitted by โˆ—athleticmedic(18)
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Findings are consistent with acute tubular necrosis

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