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Retired NBME 27 Answers

nbme27/Block 3/Question#19 (reveal difficulty score)
An 18-year-old woman comes to the physician ...
APOB ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(19)
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APO E - mediates remnant uptake (Everything Except LDL) [defective in Familial dyslipidemia type III or dysbetalipoproteinemia - premature atherosclerosis, tuberoeruptive and palmar xanthomas]

  • APO E2 decreases the risk of the sporadic form of Alzheimer's disease
  • APO E4 increases the risk of the sporadic form of Alzheimer's disease

APO AI - Found only on Alpha-lipoproteins (HDL), Activates LCAT

APO CII - Lipoprotein lipase Cofactor that Catalyzes Cleavage [defective in Familial dyslipidemia type I or hyperchylomicronemia - increased chylomicrons and increased risk of pancreatitis, hepatosplenomegaly, and eruptive/pruritic xanthomas]

APO B48 - mediates chylomicron secretion into lymphatics and is found only on particles originating from the intestines

APO B100 - Binds LDL receptors and is found only on particles originating from the liver [defective in Familial dyslipidemia type II or familial hypercholesterolemia - tendon (Achilles) xanthomas and corneal arcus]

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